What can I layer on top of tretinoin?

Author: Ms. Ivah Collier  |  Last update: Wednesday, September 24, 2025

Tretinoin should always be paired with a moisturizer and sunscreen with a SPF 50. In addition to these two items, you can also pair it up with Vitamin C (applied before your sunscreen in the morning) and hyaluronic acid or niacinamide 10 minutes after applying your tretinoin cream.

What can you layer with tretinoin?

One of the most popular hydrating ingredients, Hyaluronic acid is excellent to pair with Tretinoin in compounded treatments. It helps to counteract the dryness and flaking effects of Tretinoin by drawing moisture into the skin, keeping it plump and hydrated.

Can I put anything on top of tretinoin?

The next most important tip is to use a moisturizer with your application. There are many ways to do this — you can apply your moisturizer before tretinoin; after tretinoin; before AND after tretinoin (the “sandwich method”); or you can mix the tretinoin into your moisturizer.

What serums can I use with tretinoin?

Which skin products are compatible with tretinoin? Hyaluronic acid is the standout topical compatible with virtually everything, followed by niacinamide. Some prescription formulations combine retinoids with other ingredients such as hydroquinone.

What should you not mix with tretinoin?

Unless your doctor tells you otherwise, it is especially important to avoid using the following skin products on the same area as tretinoin: Any other topical acne product or skin product containing a peeling agent (eg, benzoyl peroxide, resorcinol, salicylic acid, or sulfur).

TRETINOIN - THE GREATEST LIE EVER TOLD!

What is the best pair to tretinoin?

Tretinoin should always be paired with a moisturizer and sunscreen with a SPF 50. In addition to these two items, you can also pair it up with Vitamin C (applied before your sunscreen in the morning) and hyaluronic acid or niacinamide 10 minutes after applying your tretinoin cream.

What ingredients cancel out tretinoin?

Avoid other topical retinoids, and skin care products containing retinol, with tretinoin. You may also want to avoid salicylic acid, glycolic acid, and erythromycin gel (Erthygel), as these ingredients and products can cause dryness.

Can I put hyaluronic acid over tretinoin?

Can You Use Tretinoin and Hyaluronic Acid Together? The short answer: YES. The long answer: You should use them together—but strategically. Tretinoin works hard to renew your skin, but it can leave it dry and sensitive in the process.

What is the sandwich method of tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

Is tretinoin 3 times a week enough?

When you first start using tretinoin, you may start with a lower percentage that you apply just two or three times a week. After two weeks, if your skin is adjusting well to the tretinoin, you can consider increasing use to every night as tolerated.

What can I put on my face after tretinoin?

Using a water-based moisturizer after applying tretinoin is generally recommended. This can help protect your skin from some side effects of the treatment, including dryness, peeling, and irritation.

Can I use tretinoin with niacinamide?

While tretinoin and niacinamide can be used together, it's important to introduce each ingredient gradually and use caution to avoid any adverse reactions. It's generally recommended to use tretinoin at night and niacinamide in the morning to avoid any potential conflicts between the two ingredients.

What happens if I put too much tretinoin on my face?

Applying excessive amounts of tretinoin onto the skin to make acne go away faster will not work. This can make the skin worse by causing extreme dryness, peeling, or redness. It may take up to six weeks of tretinoin treatment to see results. Make sure to use sunscreen, especially in the summertime.

What combos with tretinoin?

Dr Malvina Cunningham: Retinoids like tretinoin and vitamin C work well together as they both promote collagen production and enhance each other's effect. Vitamin C is generally less of an irritant so these can often be applied in combination. Retinoids like tretinoin and niacinamide work well too.

How can I make tretinoin more effective?

You can further boost the efficacy of both retinol and tretinoin by exfoliating for better penetration. Treatments featuring the alpha hydroxy acid (AHA), glycolic acid, can be great for unblocking the skin's surface by removing dead cells.

What is the best peptide serum for face?

Our Top Peptide Serums
  • Best for Inflammation: Eighth Day Regenerative Serum, $195.
  • Best for Dullness: Best for Dullness: Drunk Elephant Protini Powerpeptide Resurf Serum, $82.
  • Best Budget: The Ordinary Multi-Peptide + Copper Peptides 1% Serum, $32.
  • Best Eye Cream: Dermalogica Phyto Nature Lifting Eye Cream, $127.

How do you layer tretinoin with other serums?

Be cautious about mixing tretinoin with skin products that contain vitamin C, benzoyl peroxide or salicylic acid. You can use these ingredients as part of your Retin A skin care routine if you apply them in the morning (having applied tretinoin the night before), but only after you've thoroughly washed off tretinoin.

What makes tretinoin less effective?

Using Tretinoin Correctly

The best time to use Tretinoin is at night. This is because light can degrade Tretinoin and make it less effective. Even more importantly, your skin regenerates the most at night and so your skills will get the maximum benefits from Tretinoin when it is applied during this period.

How do you start a tretinoin purge?

What does skin purging look like? It can cause side effects like redness, swelling, dryness, itchiness and possibly more pimples than when you started. This is because Tretinoin boosts the rate of skin cell turnover to help prevent your pores from getting clogged and turning into acne.

What is the best nighttime moisturizer after tretinoin?

1. The best night cream to use with tretinoin cream. The La Roche-Posay Cicaplast Baume B5 Multi-Purpose Balm. This multi-purpose repairing cream was specifically created to soothe irritated dry skin.

Does tretinoin peeling ever stop?

Some people may notice that this side effect goes away within a few weeks of use, while others may have flaky skin for up to two months. Regardless of how long it takes to subside, tretinoin peeling is temporary and will go away once your skin gets used to the product.

What does retinol burn look like?

The skin goes red, inflamed, and peeling because retinol has chemically burned away the upper layer of skin, the new exposed skin has not had enough time to build up its natural protection film to UV light and pollutants that a good UV moisturising oil can help with and reduce the exposure to skin cancer risk, ...

What deactivates tretinoin?

The tretinoin in Retin A cream is very prone to break down by exposure to light. UVA breaks down tretinoin the most but the peak wavelength that does this is 420nm, which is just into the visible light spectrum right outside of the UVA wavelength spectrum.

Is topical tretinoin bad for the liver?

Retinoids have been implicated in causing mild-to-moderate elevations in routine liver tests, but these elevations are usually asymptomatic and transient, resolving spontaneously even with continued therapy.

What is the next best thing to tretinoin?

Retinaldehyde is considered the closest over-the-counter alternative to tretinoin and is suitable for all skin types. It provides comparable skin renewing benefits while being less irritating, making it a suitable choice for those looking for effective yet gentle retinoid options.

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