Alternative lightening agents including mequinol, arbutin, kojic acid, and others have shown comparable efficacy to hydroquinone in treating hyperpigmentation with less concerning side effects.
Conclusions. We conclude that azelaic acid may be better than hydroquinone in reducing melasma severity as measured by the MASI. However, no significant difference between both treatments regarding the side effects.
Instead of powerful whitening agents like hydroquinone, K-beauty products typically rely on niacinamide, which is also used by many mainstream Western beauty brands, including Olay. You'll also find plenty of arbutin, a gentler and safer chemical cousin of hydroquinone.
Kojic Acid offers antioxidant support and brightens skin tone while Niacinamide helps to improve pigmentation, resulting in a more flawless, radiant complexion.
Arbutin. According to Dr. Green, “Arbutin is a natural form of hydroquinone derived from the bearberry plant. It is a safer and effective alternative to hydroquinone and is less cytotoxic to the melanocytes.” Use it gradually during the first few weeks to make sure your skin doesn't react.
10% azelaic acid over the counter products have also been shown to improve hyperpigmentation concerns such as post-inflammatory hyperpigmentation from acne, sun spots, and melasma; the results being equal to 4% pharmaceutical HQ. Kojic acid is another acid that specializes in reducing unwanted pigment within the skin.
In China, Korea, and Japan, washing one's face with rice water was also practiced, as it was believed to naturally whiten skin. Historians also noted that as East Asian women immigrated to the United States, immigrant women engaged in skin lightening more frequently than women who did not immigrate.
All patients showed pigment improvement with both treatments. Colorimetric measures did not show statistical differences between both sides. However, good to excellent improvement was observed with niacinamide in 44% of patients, compared to 55% with HQ.
Conclusion: The results of the study show that 4% Hydroquinone cream is a better topical hypopigmenting agent with rapid rate of clinical improvement when compared to 0.75% Kojic Acid cream.
Avoid using hydroquinone with peroxide products such as benzoyl peroxide or hydrogen peroxide, which can cause discoloration. 3. Avoid alpha hydroxy acids. The combination of hydroquinone and alpha hydroxy acids (AHAs) can irritate your skin.
Results Hydroquinone treatment alone and treatment with the combination of hydroquinone and glycolic acid had a significant effect in reducing skin pigmentation compared with baseline (P<. 001). However, no significant difference was found using combination therapy compared with hydroquinone alone (P = . 75).
No, azelaic acid does not have the capability to permanently lighten your skin - it is not destroying melanin - it simply disrupts/slows melanin production.
The best alternative to Hydroquinone is a product called Cyspera, which effectively reduces pigmentation marks and banishes melasma, leaving a naturally clearer complexion. Its key active ingredient is cysteamine, which is proven to be even more effective than Hydroquinone.
Hydroquinone (HQ)
HQ is the agent of choice for skin lightening. Combining HQ with a steroid cream and tretinoin have superior efficacy when compared to HQ alone. Although it's considered safe, there may be side effects and is subject to pre-market approval by Health Sciences Authority (HSA).
The first 3 months HQ is applied twice a day, following the below schedule and the following 3 months the patient should follow the below wean off schedule. HQ should not be abruptly stopped due to certain side effects such as paradoxical postinflammatory hypermelanosis.
If you want to try an over-the-counter fade cream, choose one that contains hydroquinone, glycolic acid or kojic acid. Some products, especially those that contain hydroquinone, may cause skin irritation. You could also apply makeup to help make age spots less noticeable.
This study shows that 20% azelaic acid cream applied topically twice daily over a period of 24 weeks and used concomitantly with a broad-spectrum sunscreen is effective in reducing or clearing melasma. Azelaic acid cream was clearly superior to the 2% hydroquinone cream employed in the control group.
Two of the best are vitamin C and retinol. While there's almost nothing vitamin C can't do, it's truly an essential for reducing dark spots because it can help inhibit tyrosinase (an enzyme that triggers melanin production). Tyrosinase is also no match for all-powerful retinol.
Most commonly, celebrities resort to chemical peels or laser therapy to get rid of hyperpigmentation fast. Others opt for vitamin C supplements, retinol, or serums to lighten their skin.
Japanese pharmaceutical cosmetics, often referred to as quasi-drugs, contain skin-lightening active ingredients formulated to prevent sun-induced pigment spots and freckles. Their mechanisms of action include suppressing melanin production in melanocytes and promoting epidermal growth to eliminate melanin more rapidly.
Natural ingredients like lemon, turmeric, aloe vera, papaya, and licorice extract are known for their skin-brightening properties. They help in reducing dark spots, uneven skin tone, and hyperpigmentation, giving you a healthy and radiant complexion.
Tri-Luma (fluocinolone/hydroquinone/tretinoin) - Uses, Side Effects, and More. Overview: Tri-Luma is used to treat a condition called melasma, which is where colored areas appear on the face. Tri-Luma contains three medicines.
The most commonly used treatments for melasma are skin lightening medications that are applied topically. These include medications such as hydroquinone, azelaic acid, kojic acid, niacinamide, cysteamine, rucinol, and tranexamic acid.