What are the restrictions of hyaluronic acid?

Author: Ephraim Okuneva PhD  |  Last update: Saturday, August 23, 2025

Contraindications for the use of intraarticular hyaluronic acid include: Hypersensitivity to hyaluronic acid or any of the formulation components. History of severe allergic reaction or anaphylaxis to hyaluronic acid.

What should be avoided with hyaluronic acid?

However, there are certain ingredients that should not be mixed with hyaluronic acid:
  • AHAs and BHAs: AHAs (alpha hydroxy acids) and BHAs (beta hydroxy acids) are chemical exfoliants that can help improve skin texture and unclog pores. ...
  • Benzoyl Peroxide: Benzoyl peroxide is a common ingredient found in acne treatments.

What are the precautions for hyaluronic acid?

Avoid activities such as jogging, soccer, tennis, heavy lifting, or standing on your feet for a long time. Temporary pain or swelling in the knee joint may occur after receiving hyaluronic acid injection. Call your doctor if the pain or swelling in the knee persists or becomes worse after receiving this medicine.

Who should not take hyaluronic acid?

Allergic reaction: If you are allergic to Hyaluronic Acid, you should avoid using products that contain it. Medical conditions: If you're experiencing a medical condition, such as diabetes or a bleeding disease, or if you are pregnant or nursing, you should see a doctor before taking Hyaluronic Acid.

What is the rule of hyaluronic acid?

The Only Rule for Hyaluronic Acid? Always Apply It on Damp Skin! It might sound surprising, but when hyaluronic acid is applied to dry skin, it can have the opposite effect, leaving your skin even more dehydrated.

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Is there a downside to hyaluronic acid?

The most common adverse effects associated with hyaluronic acid filler are pain, bruising, redness, itching, and swelling. These side effects are self-limited and typically last no more than seven days.

Is hyaluronic acid hard on the liver?

10. Is Hyaluronic Acid Bad For Your Liver? In the case of patients with liver diseases, it is advised to avoid using HA as the increased levels of HA in the bloodstream can cause thrombosis. Hence, user discretion and medical supervision are advised.

What medications does hyaluronic acid interact with?

Medications known to interact with hyaluronan
  • benzalkonium chloride topical.
  • cetylpyridinium topical.
  • COVID-19 mRNA (Moderna) vaccine.
  • COVID-19 mRNA (Pfizer) vaccine.
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
  • sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)

Is it bad to take hyaluronic acid everyday?

Hyaluronic acid supplement

Hyaluronic acid supplements are generally safe, but you should tell your doctor before starting them or any other supplement.

Is hyaluronic acid bad for kidney?

AH results from HA specifically accumulating in glomerular afferent and efferent arterioles. This increased renal HA accumulation has been linked to worsened proteinuria, faster loss of kidney function, and increased cardiovascular events.

What are the complications of hyaluronic acid?

The most common complications are injection site reactions, including edema, pain, erythema, itching, and ecchymosis [14]. Other reported AEs are hypersensitivity reactions, infections, Tyndall effect, and surface irregularities and nodules [15-18].

Can you overdo it with hyaluronic acid?

While hyaluronic acid is a great hydrator, overusing it can lead to dehydrated skin. This happens because hyaluronic acid can only attract and retain a limited amount of moisture, and using too much can cause it to pull moisture from deeper layers of the skin.

What is the new injection instead of knee replacement?

For many people experiencing pain and dysfunction in their knees due to osteoarthritis, knee gel injections – a procedure also known as viscosupplementation – can provide long-lasting relief. These treatments, which have been around for about two decades, are considered very safe and have few side effects.

What does too much hyaluronic acid do to your face?

However, too much can cause it to pull moisture from deeper in the dermis into your epidermis, leaving the deeper layers of your skin dehydrated. If you choose an HA serum, apply it to damp skin. If you use an HA moisturizing cream or lotion, apply it on top of your serum.

What is the best hyaluronic acid for mature skin?

We chose OSEA Hyaluronic Sea Serum as the best for mature skin because of its impressive ability to deliver overnight hydration, leaving our skin looking fresh, plump, and radiant by morning. Mature skin often requires intense moisture to maintain elasticity and minimize fine lines, and this serum excels at both.

Is it better to use hyaluronic acid in the morning or at night?

If you have dehydrated skin, use hyaluronic acid serum both in the morning and at night. In the morning, it might help hydrate your skin and prepare it for the day ahead. At night, it might help repair and rejuvenate your skin while you sleep. Be sure to follow up with a moisturizer to lock in the hydration.

What should you not mix with hyaluronic acid?

For instance, Alpha Hydroxy Acids (AHAs), such as Lactic Acid and Glycolic Acid, and Synthetic Retinol are a pair that can easily cause irritation.

Does hyaluronic acid have side effects?

There are no known side effects to topical lotions and creams with hyaluronic acid, as it's already present in your body. Still, you could have an allergic reaction to a specific formulation or brand. Potential side effects of hyaluronic acid dermal filler include: Bruising.

Who shouldn t use hyaluronic acid?

Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don't use hyaluronic acid on your skin.

What medications should you not take with collagen?

There are no well-known drug interactions and we don't yet know what the best dose of collagen is.

What does hyaluronic acid conflict with?

Hyaluronic Acid and Derivatives have no noted serious interactions with any other drugs. Hyaluronic Acid and Derivatives have no noted severe interactions with any other drugs.

Does hyaluronic acid affect your heart?

Hyaluronic acid binds water in the heart muscle and improves both the mechanical and electrophysiological functions of the heart. Thus, it was suggested that application of HA in the heart muscle after infarction could be a possible treatment 8.

Does hyaluronic acid affect the kidneys?

Over the past 15 years, HA has been observed to induce varying effects in kidney injury and disease that largely depend on the study model but are considerably influenced by its MW. For example, Ito et al. showed that HMW-HA bound to CD44 promotes proximal tubular cell (PTC) migration in vitro via MAPK activation [41].

Can hyaluronic acid cause thrombosis?

Hyaluronic acid is widely used in medical procedures such as intra-articular injections. In addition to some risks of this procedure such as sepsis and injury to neighboring structures, deep vein thrombosis and pulmonary embolism should be kept in mind as rare complications.

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