Is vitamin C or tranexamic acid better for hyperpigmentation?

Author: Mable Effertz  |  Last update: Saturday, June 14, 2025

They work in different ways, and are both beneficial. One isn't better than the other for fading dark spots. Tranexamic acid is more targeted toward reducing hyperpigmentation, while Vitamin C is better suited for general skin health and reducing all visible signs of ageing.

Is tranexamic acid better than vitamin C for dark spots?

When it comes to brightening the skin and addressing pigmentation concerns, both Vitamin C and tranexamic acid offer significant benefits. While Vitamin C provides multi-tasking benefits and can help with hyperpigmentation, tranexamic acid is a more specific ingredient for targeting dark spots and uneven skin tone.

Which acid is more effective for hyperpigmentation?

Kojic acid effectively penetrates through your skin layers and stops melanin production. This is why it is praised and readily used in hyperpigmentation treatments. The acid can also be used to prevent browning; it is a well-known and well-studied tyrosinase inhibitor.

How long does it take for tranexamic acid to fade hyperpigmentation?

It can take 8-12 weeks of regular use of tranexamic acid skin care products before you see a noticeable difference in skin tone and brightness.

Can I use vitamin C and tranexamic acid together?

There is some evidence to suggest that combining tranexamic acid (TXA) with vitamin C may have potential synergistic effects in addressing certain skin concerns. Both ingredients are known for their skin-brightening properties and can target hyperpigmentation through different mechanisms.

Tranexamic Acid for Hyperpigmentation | How to Layer and Combine for Dark Spots

What Cannot be combined with tranexamic acid?

Cautions with other medicines

Tranexamic acid can be taken with most other medicines. However, talk to your doctor or pharmacist if you're taking the combined contraceptive pill. There could be a very small increased risk of getting a blood clot if you take tranexamic acid as well.

What is the difference between vitamin C and kojic acid?

Kojic Acid is derived from fungi and works by inhibiting melanin production, helping to fade dark spots and hyperpigmentation. Vitamin C, a powerful antioxidant, protects the skin from damage caused by free radicals and promotes collagen production, leading to a firmer, more youthful appearance.

What percentage of tranexamic acid is effective for hyperpigmentation?

Results from a 12-week single-center clinical study in 55 Brazilian females revealed that a novel topical facial serum containing 3% tranexamic acid, 1% kojic acid, and 5% niacinamide was effective in treating mild-to-moderate PIH, with a significant decrease in MI at week 12 compared to baseline and control group.

Which serum is good for hyperpigmentation?

Alpha arbutin helps reduce melanin production, fade existing dark spots and prevent new ones from forming, making it a highly effective ingredient for addressing pigmentation issues. You can also use other face serums like azelaic acid, and vitamin C for pigmentation.

What to not mix with tranexamic acid?

Most frequently checked interactions
  • Acetylsalicylic Acid (aspirin)
  • Adderall (amphetamine / dextroamphetamine)
  • Adrenalin (epinephrine)
  • Benadryl (diphenhydramine)
  • Claritin (loratadine)
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Iron Sulfate (ferrous sulfate)

What fades hyperpigmentation the fastest?

Three types of skincare treatments fade hyperpigmentation marks fast:
  • Physical exfoliants.
  • Chemical exfoliants.
  • Brightening actives such as vitamin C, kojic acid, liquorice extract.

What is the number one treatment for hyperpigmentation?

Topical therapy is the recommended first-line treatment, with the gold standard being hydroquinone, which can be used alone or in combination with other agents.

How quickly does tranexamic acid work?

It can take up to 24 hours for the medicine to take full effect.

Which is better for hyperpigmentation, niacinamide or tranexamic acid?

Tranexamic acid is more effective for deeper and more stubborn hyperpigmentation such as melasma.

How long does it take for hyperpigmentation to go away with vitamin C?

Vitamin C can help reduce hyperpigmentation and even out skin tone, with noticeable results in as little as 3-4 weeks.

What vitamin C serum is best for hyperpigmentation?

Our winning pick is the SkinCeuticals C E Ferulic, a formula that I've personally used for at least three years now. Though I've tried dozens of vitamin C serums, I always come back to this one—even if it is on the pricier side—for its brightening effects.

What is the best chemical for hyperpigmentation?

Glycolic acid has now become one of the most recommended skincare ingredients for hyperpigmentation, dark spots, and dullness treatment. If you are in search of the best serum for hyperpigmentation, you can choose the one that comes with glycolic acid.

Is vitamin c or tranexamic acid better?

One isn't better than the other for fading dark spots. Tranexamic acid is more targeted toward reducing hyperpigmentation, while Vitamin C is better suited for general skin health and reducing all visible signs of ageing. Most people will benefit from using both, because each one targets different aspects of skin care.

How long does tranexamic acid take to work on hyperpigmentation?

HOW LONG DOES TRANEXAMIC AICD TAKE TO WORK ON HYPERPIGMENTATION? Products can take up to six weeks to show full results, due to the time it takes for your skin cells to turnover and the results of any products to reach the surface.

Is niacinamide or vitamin c better for hyperpigmentation dermatologist?

Unlike niacinamide, Vitamin C can be irritating, especially for sensitive skin, and may not pair well with certain ingredients like retinol due to its low pH. Both niacinamide and ascorbic acid are effective for reducing hyperpigmentation, but they work best when used together.

Is it OK to use kojic acid and Vitamin C together?

One compatible ingredient that can be used with Kojic acid is Vitamin C. When combined, this blend of these active ingredients can boost the skin's brightening and antioxidant effects. Vitamin C helps to further inhibit melanin production and promote collagen.

Which is better for hyperpigmentation, Vitamin C or alpha arbutin?

Arbutin gives quicker results than vitamin C. Arbutin acts as hydroquinone, which means it has depigmenting factors. Vitamin C is not easily absorbed into the skin, whereas arbutin absorbs quickly into the skin. That's why arbutin is the best ingredient to include in your skincare routine.

What is more powerful than kojic acid?

How is alpha arbutin better than kojic acid? It is gentle on the skin: Unlike kojic acid, which can cause stinging, irritation, or redness, alpha arbutin is much milder, making it suitable for all skin types.

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