Is tranexamic acid better than retinol?

Author: Glenna Leuschke PhD  |  Last update: Friday, June 27, 2025

Tranexamic acid is generally milder than retinol or retinoids, and less likely to cause side effects. Tranexamic Acid mainly targets hyperpigmentation issues, including melasma and dark spots.

What are the disadvantages of tranexamic acid on skin?

The most common potential side effects are listed below. Though reported instances are rare, tranexamic acid can cause allergic reactions, such as itching, swelling, hives, or a rash.

Can you use retinol and tranexamic acid together?

Yes, formulas containing tranexamic acid can be used with retinol. It is recommended that tranexamic acid formulas for the skin be applied before retinol.

Why tranexamic acid is the best?

Tranexamic acid (sometimes shortened to TXA) is a medicine that controls bleeding. It helps your blood to clot and is used for nosebleeds and heavy periods. If you're having a tooth taken out, using tranexamic acid mouthwash can help stop bleeding.

Does tranexamic acid lighten skin?

Tranexamic acid can fade dark spots and sun spots and make areas of hyperpigmentation appear lighter. Topical tranexamic acid can be used for treating melasma, chronic urticaria, post-inflammatory hyperpigmentation, and rosacea. It can also be used for post-acne erythema treatment (redness and acne scars).

Doctor V - Tranexamic Acid Vs Alpha Arbutin For Pigmentation | Skin Of Colour | Brown Or Black Skin

How long does it take for tranexamic acid to fade hyperpigmentation?

How long should you take oral tranexamic acid for melasma to see gains? Oral tranexamic acid treatment benefits maximize after taking it for eight to twelve weeks. During this time, it limits a cellular process involved in producing melanin, the pigment that makes your skin dark and causes freckles.

Which acid is best for hyperpigmentation?

Salicylic acid

It is an exfoliating agent that removes dark spots and acne-causing bacteria along with dead skin cells that can lead to pigmentation. However, you need to be patient while using salicylic acid to treat hyperpigmentation.

What to not mix with tranexamic acid?

Most frequently checked interactions
  • Acetylsalicylic Acid (aspirin)
  • Adderall (amphetamine / dextroamphetamine)
  • Adrenalin (epinephrine)
  • Benadryl (diphenhydramine)
  • Claritin (loratadine)
  • Cymbalta (duloxetine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Iron Sulfate (ferrous sulfate)

Which is better for hyperpigmentation tranexamic acid or vitamin C?

Tranexamic acid and Vitamin C are both effective ingredients for treating hyperpigmentation. They work in different ways, and are both beneficial. One isn't better than the other for fading dark spots.

Does tranexamic acid cause weight gain?

It's effects are reversible. Possible unwanted side effects: Many women stop having periods when taking this drug. Common unwanted effects include stomach pain, feeling sick, headaches, dizziness, tiredness, weight gain, hot flushes and breast tenderness. What is it?

What Cannot be combined with tranexamic acid?

Cautions with other medicines

Tranexamic acid can be taken with most other medicines. However, talk to your doctor or pharmacist if you're taking the combined contraceptive pill. There could be a very small increased risk of getting a blood clot if you take tranexamic acid as well.

How quickly does tranexamic acid work?

It can take up to 24 hours for the medicine to take full effect.

Should you use moisturizer after tranexamic acid?

To get the best out of Tranexamic Acid in your usual routine, apply as the last product. If you wish to use a moisturizer, we suggest waiting until Tranexamic Acid has completely absorbed. Top tip! Do your routine and wait 30 mins.

Is tranexamic acid good for aging skin?

Recent studies have reported the use of tranexamic acid as an anti-inflammatory agent to improve dryness-induced wrinkles and pigmentation caused by ultraviolet radiation.

Who shouldn't use tranexamic acid?

You should not use this medication if you are also using combination hormonal contraception because it may increase your chance of having a blood clot, heart attack, or stroke. Your risk is even higher if you are overweight, if you smoke cigarettes, or if you are over 35 years of age.

What is a natural alternative to tranexamic acid?

Additionally, a systematic review of three clinical trials found that ginger capsules and myrtle fruit syrup significantly reduced menstrual duration and blood loss compared to a placebo 4. Pomegranate flower capsules were also as good as tranexamic acid at reducing blood loss 4.

How to layer tranexamic acid and retinol together?

Yes, you can definitely use tranexamic acid with retinol. I personally use the duo to help keep breakouts in check and fade post-inflammation hyperpigmentation at the same time. Dr. Kim recommends using a serum with tranexamic acid in the morning and then an OTC or Rx retinoid in the evening.

Is tranexamic acid or niacinamide better?

Niacinamide is also known for its anti-inflammatory properties which makes it useful for those with acne prone or sensitive skin. Tranexamic acid is more effective for deeper and more stubborn hyperpigmentation such as melasma. Good news though is that Niacinamide and Tranexamic acid can work well together.

Should I use vitamin C or retinol for hyperpigmentation?

The choice should come down to what you're looking to do for your skin. While vitamin C is most notable for helping to brighten and improve hyperpigmentation, retinol is typically considered best-in-class for wrinkles and fine lines.

What is the disadvantage of tranexamic acid?

This medicine may increase your or your child's risk of developing blood clots. Check with your doctor right away if you or your child have swelling and pain in your arms, legs, or stomach, chest pain, trouble breathing, loss of sensation, confusion, or problems with muscle control or speech.

What is the best tranexamic acid serum?

Vogue's Favorite Tranexamic Acid Serums:
  • Best Overall: SkinCeuticals Discoloration Defense, $110.
  • Best Mature Skin: Remedy Nightly All-in-One Treatment for Dark Spots, $38.
  • Best for Sensitive Skin: Naturium Tranexamic Topical Acid 5%, $20.
  • Best for Acne-Prone Skin: Vichy LiftActiv Specialist B3 Serum, $45.

Can you take vitamin D with tranexamic acid?

Interactions between your drugs

No interactions were found between tranexamic acid and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Which acid is best for anti-aging?

Alpha hydroxy acid (AHA) and beta hydroxy acid (BHA) are two main classes of hydroxy acids. AHA is used in the treatment of several skin conditions such as acne, scar, pigmentation, skin dryness and wrinkles.

What is the number one treatment for hyperpigmentation?

Topical therapy is the recommended first-line treatment, with the gold standard being hydroquinone, which can be used alone or in combination with other agents.

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