Is niacinamide or glycolic acid better for hyperpigmentation?

Author: Frederick Johnston  |  Last update: Sunday, July 13, 2025

Niacinamide is generally considered more effective for hyperpigmentation as it inhibits melanin production. Glycolic acid works by increasing cell turnover to reveal newer skin. Using both can provide a powerful approach.

Can niacinamide remove hyperpigmentation?

In the clinical studies, niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use. Conclusions: The data suggest niacinamide is an effective skin lightening compound that works by inhibiting melanosome transfer from melanocytes to keratinocytes.

Which acid is best for hyperpigmentation?

Salicylic acid

It is an exfoliating agent that removes dark spots and acne-causing bacteria along with dead skin cells that can lead to pigmentation. However, you need to be patient while using salicylic acid to treat hyperpigmentation.

Can you use glycolic acid and niacinamide together?

If you mix glycolic acid with niacinamide, the latter will increase the pH level of glycolic acid and it will no longer be acidic. Using these two ingredients together at the same time can cause redness and itchiness on your skin.

Is glycolic acid or niacinamide better for dark spots?

Niacinamide is generally considered more effective for hyperpigmentation as it inhibits melanin production. Glycolic acid works by increasing cell turnover to reveal newer skin. Using both can provide a powerful approach.

Top 5 Serums That Will Change Your Skin in 2025!

What should you not mix with niacinamide?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

How long does it take for glycolic acid to lighten hyperpigmentation?

The Ordinary glycolic acid toner often shows initial results within one to two weeks. Better results, such as even skin tone and reduced dark spots, generally appear after four weeks of regular use.

What is the best way to get rid of hyperpigmentation?

Topical therapies (creams and lotions applied to the skin) are the most common treatment option for hyperpigmentation. Combination therapy, in which multiple topical treatments are used together, is usually most effective in treating hyperpigmentation. The most common cause of hyperpigmentation is sun exposure.

Which is better for hyperpigmentation, vitamin C or glycolic acid?

Yes, but glycolic acid is better for normal to dry skin, while vitamin C works well for all skin types, especially those prone to dullness or pigmentation.

Which serum is best for hyperpigmentation?

Shop the Best Hyperpigmentation Serums
  • Best Overall. SkinMedica Even & Correct Advanced Brightening Treatment. Read more.
  • Best for Sun Spots. La Roche-Posay Mela B3 Dark Spot Serum. Read more.
  • Best for Mature Skin. Dr. Loretta Anti-Aging Repair Serum. Read more.

Which is better for hyperpigmentation, vitamin C or niacinamide?

Both ingredients can fade hyperpigmentation and increase collagen production. Vitamin C (depending on the percentage) can be more harsh for sensitive skin types. Or, you might want to use niacinamide if you have acne-prone skin, and leverage Vitamin C for fading post-acne marks and dark spots.

What percentage of niacinamide is effective for hyperpigmentation?

For general skin tone correction, a niacinamide concentration between 4-5% is often effective and well-tolerated by most individuals. For those looking to tackle more pronounced hyperpigmentation, a higher concentration of 10% may be beneficial, though it's important to monitor the skin for any signs of irritation.

What is the best ingredient for hyperpigmentation?

Hydroquinone. Topical HQ is regarded as the gold standard for the treatment of facial hyperpigmentation. HQ is a bleaching agent that acts by inhibiting tyrosinase to limit melanin production in the skin.

Which is better for dark spots, niacinamide or retinol?

Niacinamide and retinol are popular skin care ingredients that can treat acne, hyperpigmentation, and signs of aging. While they have similar effects, retinol is more potent. However, it may also cause more significant side effects. It is possible to use the ingredients alone or in combination.

What really fades hyperpigmentation?

“Treatments containing ingredients like vitamin C, licorice root, and kojic acid help reduce hyperpigmentation by inhibiting tyrosinase, an enzyme responsible for the formation of skin-darkening melanin," says Ni'Kita Wilson, a cosmetic chemist in New York City.

What chemical is best for hyperpigmentation?

Treatment: Ingredients like hydroquinone, tretinoin, tazarotene, glycolic acid, azelaic acid, niacinamide, tranexamic acid, thiamidol, kojic acid, and vitamin C are highlighted for their roles in treating hyperpigmentation by lightening dark spots and promoting an even skin tone.

What permanently lightens hyperpigmentation?

CO2 Laser Resurfacing is the most effective non-surgical method to improve the appearance of your skin overall and hyperpigmentation specifically. It uses highly specialized lasers to remove dead and damaged skin cells and stimulate collagen production.

Is glycolic acid 7% good for hyperpigmentation?

Glycolic acid can be an effective ingredient for reducing hyperpigmentation. However, strong or irritating skin care products can also cause hyperpigmentation. It is especially important for people who are prone to hyperpigmentation to use nonirritating, gentle exfoliants.

What is the difference between glycolic acid and niacinamide?

Both ingredients offer anti-aging benefits: - Glycolic acid promotes collagen production and cell turnover. - Niacinamide improves skin elasticity and reduces fine lines. For mature skin, consider using a glycolic acid serum a few times a week and a niacinamide moisturizer daily.

Why is my skin getting darker after using glycolic acid?

“Those with darker skin tones, need to be cautious with glycolic acid,” warns Dr Buldeo. “It can cause a paradoxical darkening of the skin by stimulating melanocytes,” These are the melanin-producing cells in your skin's deepest layer so this can lead to hyperpigmentation in black skin.

What cancels out niacinamide?

Niacinamide and vitamin C

This combination sparks a lot of debate among skincare experts. Some say that since both niacinamide and vitamin C contain antioxidants, they cancel each other out and might even lead to irritation.

Can I mix niacinamide with glycolic acid?

Even though niacinamide and glycolic acid are both natural and have similar benefits, it is not advisable to use them together because of their pH levels. While niacinamide has a much higher pH level than glycolic acid, it won't get completely absorbed into the skin.

What reacts badly with niacinamide?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

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