Is it OK to apply hyaluronic acid after vitamin C?

Author: Mara Nienow  |  Last update: Monday, October 27, 2025

To layer vitamin C and hyaluronic acid serums, always apply vitamin C first to cleansed, dry skin. Be sure to leave time for your vitamin C to sink in, then follow up with your hyaluronic acid. A prime example of vitamin C and hyaluronic acid joining forces is Lancôme's Advanced Génifique.

Should I use hyaluronic acid before or after vitamin C?

When used together, they create a synergistic effect, enhancing each other's effectiveness. To maximize their benefits, apply a hyaluronic acid serum to replenish moisture, followed by a vitamin C serum to boost radiance and protect against environmental damage.

What should you not use after vitamin C serum?

Beta Hydroxy Acids

So that salicylic acid of yours should not be mixed with your vitamin C serum. It won't be able to help you with discoloration, collagen production, or protect you from UV rays. Additionally, combining the two can cause irritation and dryness.

What is more important, vitamin C or hyaluronic acid?

Vitamin C brings antioxidant protection and brightening, while Hyaluronic Acid provides deep hydration and plumpness. Incorporating both into your routine, based on your skin's needs, can lead to a well-rounded and effective skincare regimen, promoting a healthier and more radiant complexion.

What should you not mix with hyaluronic acid?

For instance, Alpha Hydroxy Acids (AHAs), such as Lactic Acid and Glycolic Acid, and Synthetic Retinol are a pair that can easily cause irritation.

Serum Basics and Common Mistakes

What is the best pair for hyaluronic acid?

As a pair, vitamin C and hyaluronic acid benefit the skin in numerous ways, though the duo is most often used to help combat the visible signs of aging.

What can't you mix with vitamin C?

Vitamin C is effectively an acid (it's sometimes known as ascorbic acid), so layering it with AHAs and BHAs like glycolic, salicylic, and lactic acids is a big no-no.

Is it better to use hyaluronic acid in the morning or at night?

Incorporating a hyaluronic acid serum into your skincare regimen is easy. This versatile ingredient can be used morning and night and works well with other formulations. As always, we recommend following the 3 core stages of a skincare regimen to layer your formulations.

What happens if you use too much vitamin C serum?

One of the most common side effects of using a Vitamin C serum is skin irritation. This can include redness, itching, and burning. This is often caused by the high concentration of Vitamin C in the serum, which can be too strong for some people's skin.

What can you layer with vitamin C?

What Can You Mix with Vitamin C?
  • Peptides. Can you mix peptides and vitamin C? ...
  • Vitamin E. Vitamin C and E are a highly efficacious ingredient combination, as vitamin E is also an antioxidant. ...
  • Ferulic Acid. ...
  • Hyaluronic Acid. ...
  • Niacinamide. ...
  • Hydroxy Acids. ...
  • Salicylic Acid. ...
  • Retinol.

What cancels out vitamin C?

Vitamin C + Niacinamide

However, when you combine niacinamide with Vitamin C, they'll cancel each other out chemically, making both formulas ineffective on your skin. Niacinamide takes out all the good properties of Vitamin C and makes it into a substance that can cause redness and trigger breakouts.

What are the mistakes while using vitamin C serum?

Vitamin C serums are notoriously sensitive to light, air, and heat. Exposure to these elements can cause the serum to degrade, leading to reduced effectiveness. Unfortunately, this is a mistake that many people overlook.

In what order do you apply hyaluronic acid?

Moisturize: Some experts recommend applying Hyaluronic Acid serum directly onto fresh, damp skin, then layering a cream or oil on top to lock moisture in.

Should I apply vitamin C at night or morning?

While you can work your vitamin C serum into either your morning or evening skincare routine, most dermatologists recommend the morning [2]. This keeps your skin protected from free radicals as you go about your day, and can work especially well with your sunscreen to keep you safe from UV radiation.

Can you use hyaluronic acid with vitamin C for skin?

Combining these two ingredients can maximise the benefits of each. While vitamin C protects and brightens the skin, hyaluronic acid hydrates and plumps it. When used together, they can enhance each other synergistically, leading to brighter, more hydrated skin.

What should be avoided with vitamin C?

Vitamin C should not be mixed with acids, which includes all AHAs and BHAs. Vitamin C plays a key role in strengthening the outer layer of our skin barrier, but when combined with an acid, it can enhance the potency of your vitamin C and cause severe irritation [5].

Which serum is best for clear and glowing skin?

To attain radiant skin, look for serums containing:
  • Vitamin C: Boosts skin's natural glow and reduces dark spots & pigmentation.
  • Niacinamide: Brightens skin and fades blemishes.
  • Hyaluronic Acid: Provides intense hydration and plumps up skin.
  • Alpha Hydroxy Acids (AHAs): Promotes cell turnover for smoother skin texture.

Can you overuse vitamin C on your face?

Using Too Many Products with Vitamin C

Using multiple products with vitamin C can cause irritation, redness, and inflammation, so it's best to limit the number of products you use.

Can I use hyaluronic acid under my eyes?

Can I use hyaluronic acid under eyes? Yes! Hyaluronic acid formulas made specifically for the eye contour area can be both essential and effective. Thanks to its ability to bind to water, this hydrating ingredient can help restore elasticity and moisture levels around the eyes as well.

What order should I do my skincare?

The right morning routine will help your skin feel calm and hydrated all day long.
  1. Step 1: Cleanser. A clean face is your starting point for a healthy, glowing complexion. ...
  2. Step 2: Toner. ...
  3. Step 3: Serum. ...
  4. Step 4: Moisturizer. ...
  5. Step 5: Eye Cream. ...
  6. Step 6: Sunscreen.

How to layer vitamin C and hyaluronic acid?

Allow 1-2 minutes between the application of each serum for full absorption of the vitamin C by your skin before you apply the hyaluronic acid. This ensures that both ingredients can work together effectively.

What is a bad combination with vitamin C?

Skincare ingredients not to mix with vitamin C

Vitamin C, AHAs (glycolic acid), and BHAs (salicylic acid) are acidic in nature. Layering them together can lower the skin's pH, making it more acidic. When skin pH goes off balance, it becomes a recipe for skin irritation, redness, and peeling.

What are the best hyaluronic acid serums?

Our Top Picks
  • Best Hyaluronic Acid Serum Overall: SkinCeuticals Hyaluronic Acid Intensifier Multi-Glycan, $182.
  • Best for Fine Lines: Alastin HA Immerse Serum, $127.
  • Best Custom Serum: Prose Custom Serum, $64.
  • Highest HA Concentration: Peter Thomas Roth Water Drench Hyaluronic Cloud Serum, $68.

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