How to layer vitamin C and tranexamic acid?

Author: Mr. Darius Zboncak  |  Last update: Thursday, June 12, 2025

apply your vitamin c serum first then layer it up your TRANEXAMIC acid serum for the best results!

How do you layer tranexamic acid?

However, it is most common to find tranexamic acid in serum form, which can be used immediately before niacinamide. In the morning, use tranexamic acid and niacinamide before sunscreen; at nighttime, layer it under your preferred retinoids/retinol.

What not to layer with tranexamic acid?

It's important to check labels of skincare products before introducing tranexamic acid into your skin care routine. Avoid using other actives (brightening agents) such as azelaic acid, kojic acid, hyaluronic acid, alpha arbutin, and licorice root at the same time.

Which is better for hyperpigmentation tranexamic acid or vitamin C?

Tranexamic acid and Vitamin C are both effective ingredients for treating hyperpigmentation. They work in different ways, and are both beneficial. One isn't better than the other for fading dark spots.

In what order should vitamin C be applied?

Generally speaking, the best time to apply vitamin C serum is in the morning, after cleansing and toning your complexion, and before moisturizer and SPF. If you want to maximize the perks, and don't have overly sensitive skin, you can apply it in the morning and evening.

Tranexamic Acid for Hyperpigmentation | How to Layer and Combine for Dark Spots

What to layer over vitamin C serum?

For even-looking skin, pair Vitamin C derivatives with Glycolic Acid. For smoother-looking skin, pair Retinaldehyde and Hyaluronic Acid. For clearer-looking skin, pair Salicylic Acid and Niacinamide 10% + Zinc 1%. For hydrated skin, pair Hyaluronic Acid and Niacinamide.

Do you use vitamin C serum before or after ampoule?

Cleanse your face as the first step in your morning skincare routine. Then use the serum, carefully shaking the Skin Complex Advanced ampoule.

Does tranexamic acid interact with vitamin C?

Interactions between your drugs

No interactions were found between tranexamic acid and Vitamin C.

How many days will tranexamic acid take to work on hyperpigmentation?

Oral tranexamic acid treatment benefits maximize after taking it for eight to twelve weeks. During this time, it limits a cellular process involved in producing melanin, the pigment that makes your skin dark and causes freckles.

What is a good combination with tranexamic acid?

Niacinamide, Vitamin C, and hyaluronic acid are excellent companions, as they further enhance skin brightening, hydration, and overall skin health. However, it is crucial to ensure that these combinations are stable and do not cause any adverse reactions.

What should you not mix with vitamin C serum?

Beta Hydroxy Acids

So that salicylic acid of yours should not be mixed with your vitamin C serum. It won't be able to help you with discoloration, collagen production, or protect you from UV rays. Additionally, combining the two can cause irritation and dryness.

What Cannot be combined with tranexamic acid?

Cautions with other medicines

Tranexamic acid can be taken with most other medicines. However, talk to your doctor or pharmacist if you're taking the combined contraceptive pill. There could be a very small increased risk of getting a blood clot if you take tranexamic acid as well.

Does tranexamic acid cause weight gain?

It's effects are reversible. Possible unwanted side effects: Many women stop having periods when taking this drug. Common unwanted effects include stomach pain, feeling sick, headaches, dizziness, tiredness, weight gain, hot flushes and breast tenderness. What is it?

How to layer vitamin C and alpha arbutin?

After cleansing, apply vitamin C serum. Let it absorb fully, then apply alpha arbutin.

Can I pair retinol with tranexamic acid?

Unlike many other acids, which are reactive with other elements and thus need to be used with extra care, tranexamic acid works well with retinol and vitamin C. I also act well with exfoliants like glycolic acid and salicylic acid.

How to layer tranexamic acid?

Yes, it is suitable to layer with Niacinamide and all other ingredients in your AM or PM skincare routine. To get the best out of Tranexamic Acid in your usual routine, apply as the last product. If you wish to use a moisturizer, we suggest waiting until Tranexamic Acid has completely absorbed.

Is tranexamic acid more effective than vitamin C?

Results: At the end of 8 weeks, MASI, PGA and PtGA showed improvement with both tranexamic acid and vitamin C. However the improvement was more with tranexamic acid than with vitamin C, although not statistically significant.

What to avoid with tranexamic acid?

You should not use this medication if you are also using combination hormonal contraception because it may increase your chance of having a blood clot, heart attack, or stroke. Your risk is even higher if you are overweight, if you smoke cigarettes, or if you are over 35 years of age.

Can I use moisturizer on top of tranexamic acid?

Apply an even layer of the tranexamic acid serum onto face, neck and chest, avoiding the eye area. For best results, follow with a moisturizer. If mild sensitivity or redness occurs, reduce frequency of use until skin adjusts. Wear SPF during the day.

What happens if you take tranexamic acid too close together?

Taking 1 extra dose of tranexamic acid is unlikely to harm you. However, if you take too much you may get side effects. These can include feeling or being sick, diarrhoea and feeling dizzy. Speak to your doctor if you're worried or if these side effects are troubling you.

What order do you put vitamin C and serum?

Dermatologists recommend you apply vitamin C serum before you apply moisturiser and sunscreen. The steps for application are [2]: Use a gentle cleanser to remove any makeup or free radicals from your skin. Apply a few drops of vitamin C serum to your face and neck, and gently rub it in.

What should you not do after applying vitamin C serum?

Not using sunscreen:

Vitamin C serum can make the skin even more sensitive to the sun, making it especially important to use a broad-spectrum sunscreen with an SPF of 30 or higher to protect the skin from UV damage.

How long does vitamin C serum take to work for hyperpigmentation?

Within one week of starting to use this product, your skin will get better hydration, and your complexion will brighten. Even for hyperpigmentation, Vitamin C serum before and after changes are pretty evident. You will usually notice a reduction in dark spots within two weeks of using this product.

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