How to get clear skin with tretinoin?

Author: Dr. Ruby Thompson  |  Last update: Monday, November 3, 2025

Expert tips on using tretinoin in skincare treatment
  1. Cleanse and wait 10-20 minutes before applying tretinoin. ...
  2. Start small and increase slowly. ...
  3. Ensure proper application of tretinoin. ...
  4. Make it a part of your nighttime routine. ...
  5. Integrate it in with your other products.

How long does it take to get clear skin with tretinoin?

It may take longer than 12 weeks before you notice full improvement of your acne, even if you use the medicine every day. Check with your doctor if skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks.

How do you maximize tretinoin results?

To maximize the results of tretinoin, start slowly, apply tretinoin at night on perfectly dry skin and between two layers of moisturizer, wear sunscreen with SPF 50 every morning, and combine with niacinamide or hyaluronic acid to minimize irritation.

How to increase the efficacy of tretinoin?

You can further boost the efficacy of both retinol and tretinoin by exfoliating for better penetration. Treatments featuring the alpha hydroxy acid (AHA), glycolic acid, can be great for unblocking the skin's surface by removing dead cells.

What enhances tretinoin?

Peptides. These are a group of amino acids that play a crucial role in skin repair and collagen production. When compounded with Tretinoin, peptides may enhance its anti-ageing benefits by helping to improve skin firmness and elasticity. They can also help reinforce the skin's barrier and improve skin texture.

how I got my dream skin *tretinoin*

Why am I not seeing results with tretinoin?

Your unique skin type

Everyone's skin is unique, and different skin types react differently to tretinoin and retinoids more generally. If you're a Dermatica subscriber, reach out to your dermatology team through your dashboard. Sometimes adjusting the concentration, or how frequently you use it, can increase results.

Is tretinoin 3 times a week enough?

When you first start using tretinoin, you may start with a lower percentage that you apply just two or three times a week. After two weeks, if your skin is adjusting well to the tretinoin, you can consider increasing use to every night as tolerated.

What not to mix with tretinoin?

You may also want to avoid salicylic acid, glycolic acid, and erythromycin gel (Erthygel), as these ingredients and products can cause dryness. Though, your dermatologist can help you decide if combining these products with tretinoin is safe. Tretinoin can also cause sun sensitivity.

What is the sandwich method for tretinoin?

Option one: The sandwich technique

After washing your face, apply a layer of moisturiser. Allow it to dry down for 5-10 minutes. Then, apply a pea-sized amount of tretinoin to your entire face. Allow this to dry down for 5-10 minutes.

How to know if tretinoin is working?

After 4-6 weeks, your skin will get used to Tretinoin and will begin to be noticeably smoother and more even. Depending on how often you use Tretinoin, you may begin to see full benefits by this point. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.

Does tretinoin make skin glowy?

A glowing, youthful complexion is the ultimate goal in skincare. Retinol and tretinoin are two powerful ingredients that can help achieve this.

Why am I still breaking out on tretinoin?

“During the skin purge, your skin speeds up the cell turnover faster than it's used to so the substances clogging your pores get pushed to the surface of your skin faster, so you may experience slight inflammation, contributing to additional breakouts,” says Dr. Fernandez.

What does tretinoin purge look like?

Skin purging is common, but doesn't necessarily happen to everyone. In fact some people don't experience it at all. For those of us who do suffer from purging, it can look like: breaking out in pustules (pimples), the appearance of flaky, peeling skin, irritation and dry patches.

What is the best tretinoin routine?

Tretinoin should be applied to the entire face nightly — AFTER washing your face and in combination with a moisturizer. When you first start tretinoin, your goal is to apply a pea-sized amount to your entire face 2-3 nights a week.

Is tretinoin good for hormonal acne?

How do I treat hormonal acne? Based on the severity of your acne, different treatment options are available to reduce sebum production, pimple formation and painful inflammation: Blackheads and whiteheads: Topical cream (tretinoin). Inflammatory acne: Topical retinoid and/or topical antibiotic and/or benzoyl peroxide.

Does tretinoin cause weight gain?

If you experience any of the following symptoms, call your doctor immediately: fever; weight gain; swelling of the arms, hands, feet, ankles, or lower legs; shortness of breath; labored breathing; wheezing; chest pain; or cough.

Does tretinoin grow hair?

Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months.

How long to let tretinoin sit before moisturizer?

Once you've massaged the Tretinoin onto your skin, you can apply your serums and/or moisturiser if you use these at night. There isn't a golden rule about how long to wait before applying these as different formulations of Tretinoin take different times to absorb. If in doubt, wait for 15-20 minutes.

Does tretinoin peeling ever stop?

Some people may notice that this side effect goes away within a few weeks of use, while others may have flaky skin for up to two months. Regardless of how long it takes to subside, tretinoin peeling is temporary and will go away once your skin gets used to the product.

Can I use vitamin C with tretinoin?

Dr Malvina Cunningham: Retinoids like tretinoin and vitamin C work well together as they both promote collagen production and enhance each other's effect. Vitamin C is generally less of an irritant so these can often be applied in combination. Retinoids like tretinoin and niacinamide work well too.

Can you put tretinoin under eyes?

Yes, tretinoin can be used to treat dark circles under the eyes. It has been found to effectively reduce darkness related to pigment and improve overall skin texture. However, it's important to consult a dermatology provider before starting tretinoin treatment for dark circles.

Why is tretinoin not clearing my skin?

Your Retinoid is Being Inactivated

Retinoids are inactivated by UV light, so must be applied at night. Additionally, retinoids can be inactivated by other topical skin care ingredients, most commonly salicylic acid. Avoid using products which contain salicylic acid in your night-time skin care routine.

What is the best cleanser for tretinoin?

Wash face thoroughly with a mild soap or a gentle alcohol-free non-soap cleanser such as Neutrogena Fresh Foaming Wash, Cetaphil cleanser, or CeraVe cleanser.

What's better, tretinoin or differin?

Both adapalene and tretinoin will effectively cure your acne and dark spots, although tretinoin is likely to produce results more quickly, but adapalene gel is less irritating for patients.

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