The lethal dose of the Botox preparation for a person of 70 kg is calculated to be 2,500-3,000 units. The recommended dose for large muscles, localized by touch, (e.g. gastrocnemius) is 100-400 units, whereas for cosmetic purposes usually less than 30 units are injected directly into the targeted muscle.
Each vial of Botox® contains 100 Units (U) of Clostridium botulinum type A neurotoxin complex, 0.5 milligrams of Albumin (Human), and 0.9 milligrams of sodium chloride in a sterile, vacuum-dried form without a preservative.
Botox Overdose
Symptoms of overdose after Botox injection may include difficulty breathing, difficulty moving parts of the body, and weakness. These symptoms may not appear right away. Call your doctor or seek emergency medical attention right away if you experience any of these symptoms.
The clinical symptoms of botulism occurred within 0∼36 days after injection, mainly between 2nd and 6th day after the operation (Fig. 3).
One gram of an aerosolized botulism toxin is enough to kill about a million people, and a human toxic dose is on the order of a billionth of a gram. However, botulinum toxin A is also the first biological toxin which is licensed as a drug for treatment of human diseases.
There are no long-term or life-threatening adverse effects related to botulinum toxin treatment for any cosmetic indications. Moreover, the risk of possible complications can be reduced by means of a thorough analysis of the patient's medical history and the use of the appropriate dose and technique for the injection.
Botox toxins are thought to remain active in the body or target area for 4 to 6 months before being metabolized and excreted from the body.
Although botulinum toxin is life threatening, small doses — like those used in the application of Botox — are considered safe. In fact, only 36 cases of adverse effects associated with cosmetic use were reported to the Food and Drug Administration (FDA) between 1989 and 2003.
Botox gets its name from the Botulinum toxin, a protein extracted from Clostridum botulinum (mentioned above). If this live bacteria enters the bloodstream, it will attach itself to muscles and replicate, weakening or completely immobilizing the muscle. This toxin is in fact quite deadly.
Survival and Complications
Today, fewer than 5 of every 100 people with botulism die. Even with antitoxin and intensive medical and nursing care, some people with botulism die from respiratory failure. Others die from infections or other problems caused by being paralyzed for weeks or months.
How much Botox is permissible on the forehead? Botox comes in dosages between 50 and 100 units per vial. Some practitioners say they inject an average of 10 to 30 units into the forehead. Allergan, the manufacturer of Botox Cosmetic, suggests a dosage of 4 units each in five sites on the forehead, totaling 20 units.
40 units is not a “large” dose for glabella, forehead, and crows feet but i'd say it's pretty typical. I have many patients that do more without looking frozen.
If you only had the crows feet and forehead areas treated, the 70 units would appear to be excessive. However, if you had the glabella of the lower forehead treated as well, it would not be unusual to have recieved 70 units for all 3 areas.
An average Botox procedure uses about 50 units at a time, with the maximum safe amount being 100 units. Typically, you can expect more Botox units if you want to target more dynamic wrinkles like frown lines, forehead lines, or smile lines.
75 units is a lot for an entire forehead! If the amount you were given was truly 75 units, you will probably be good to go for up to 4 months or longer, particularly for the forehead and muscles between the brows. Crows feet recover a bit sooner.
Although there have been recent lawsuits in the media attempting to link Botox to brain damage, there's no concrete evidence to suggest that Botox actually causes brain damage. That being said, when Botox is injected not using proper precautions, it can potentially result in nerve damage.
Time is the only antidote for botox, and there is no way to flush it out of your system.
Muscle-paralyzing drug can move from the skin to the brain
Researchers have found that botulinum neurotoxin type A--more commonly known as Botox--can migrate into the central nervous system after it's injected into the skin.
Answer: Botox not harmful to liver or kidneys.
Of half the patients who received the Botox injection, seven percent later experienced atrial fibrillation, as compared to 30 percent of patients who didn't receive the injections.
No, Botox cannot affect your kidneys because it has almost no systemic absorption.
Over time, the Botox components are broken down into harmless particles called amino acids. The broken-down components are excreted from the kidneys as waste, or they're used in other proteins. As such, Botox either leaves your system completely or gets recycled in a harmless form.
Don't lie down for at least 3 hours after receiving Botox. Don't go into any saunas, hot tubs, or tanning booths for at least 4 hours. This helps to prevent bruising, because heat can raise your blood pressure. Otherwise, you can resume your regular activities right after getting Botox.
Many people worry that if they stop getting BOTOX injections, their wrinkles will come back faster and worse than before. However, this is not the case. If you stop BOTOX injections, your wrinkles will slowly start to come back, but slower than if you had never used BOTOX to begin with.