Unfortunately, when you first start using it, your acne may get worse before it gets better. Some of the more common side effects include dry skin and chapped lips. You may also have dry nasal passages, which can make your nose bleed.
Timeline of Effects
That is why you hear some Accutane patients saying, “It gets worse before it gets better.” But this is when the pilosebaceous units shed abnormal cells and replace them with better ones. After 1-3 months, you should see your skin becoming clearer.
Some people do experience worsening if they have long-standing acne. This is usually due to purging, in which the isotretinoin pushes out dead skin cells and debris. Because your skin can become red and dry, the medication sometimes makes acne look more inflamed and obvious.
You will probably take isotretinoin for 15 to 20 weeks. Your acne may get worse when you first start using isotretinoin. This usually just lasts for a little while. If this happens to you, your doctor may have you use other medicines along with the isotretinoin in this stage.
Generally speaking, dermatologists say purging should be over within four to six weeks of starting a new skin care regimen. If your purge lasts longer than six weeks, consult your dermatologist. It could be that you need to adjust the dosage and/or frequency of application.
Take with food: Isotretinoin absorbs twice as well if you take it with meals. Isotretinoin is a lipophilic medication. One study showed 1.5-2 times greater absorption in the fed (large breakfast with 28 grams of fat) versus a fasting state. This difference in absorption is not a trivial concern.
Skin purging typically looks like tiny red bumps on the skin that are painful to touch. They are often accompanied by whiteheads or blackheads. It can also cause your skin to become flaky. The flare ups caused by purging have a shorter lifespan than a breakout.
During Your Treatment. Your acne may get worse when you start using isotretinoin. This usually just lasts for a little while. You can tell your doctor if this happens to you because you might need to use other medicines along with the isotretinoin in this stage.
The results are where Accutane® treatment really shines. Peak effect is visible at the 8-12 week mark, and patients see a difference in their skin within 2 weeks. ZENA Medical is so confident in your Accutane® protocol that we guarantee your face will be 100% pimple-free after 3 months of Accutane® therapy.
During the first 3 weeks you are taking isotretinoin, your skin may become irritated. Also, your acne may seem to get worse before it gets better. Check with your doctor if your skin condition does not improve within 1 to 2 months after starting this medicine or at any time your skin irritation becomes severe.
Isotretinoin works by reducing the production of oil on your skin, slowing down the growth of skin cells that may clog pores and killing the bacteria in your pores that cause inflammation. Dosing is important to achieve success, and when used properly, Accutane has a nearly 90% success rate.
Experience suggests that females with acne limited to the face are likely to respond to isotretinoin treatment within three months. Males with acne on their trunk or back may take five to eight months to respond to treatment with isotretinoin.
Accutane Side Effects:
Before your acne can get better, it will likely get worse at the beginning stages of taking Accutane. Called purging, the drug will push out all dead skin cells, oil, and debris from underneath the skin causing inflammation and more acne. Once this stage is complete, acne will begin to subside.
Zenovia: After getting off Accutane, it's very important to continue being diligent about skin care. Incorporating an effective spot treatment, lightweight moisturizer, sunscreen, and retinol into your routine will help keep the skin balanced and healthy.
Most patients don't see an appreciable difference until the third month of treatment. But first comes the “purge,” when all the old skin cells start rising—at an accelerated rate, with a potent retinoid—from the bottom layer of the epidermis up to the surface. “It gets worse before it gets better” is the adage.
Accutane "cures" about half of those people who take it so that they never need to do anything else for acne. In the first few weeks of treatment, about one in five patients gets a little worse, and one in 500 patients gets much worse.
Accutane works well for acne, but some people may want to avoid it due to side effects or other reasons. Alternatives include topical retinoids, benzoyl peroxide, antibiotics, hormonal medications, and steroid injections.
For best results, you should take the Accutane capsule at the same time every day with a full glass of water immediately following a meal or snack high in fat content. This ensures the medication is absorbed well and works properly.
These unwanted effects — particularly skin dryness and acne breakouts — are widely referred to as the “tretinoin purge.” While they don't affect everyone, many tretinoin users experience some degree of purge effects during the first several weeks of treatment.
Purging is a sign that the product is working and you should continue with the treatment as prescribed. After a few weeks of purging, your skin and acne will have noticeably improved. Breaking out is when your skin is reacting because it is sensitive to something in the new product.
Purging pimples do not leave marks or blemishes on your skin. It actually heals the skin to form fresher skin cells. Breakouts don't benefit the skin; they leave marks and blemishes when they go. The cell turnover is faster to remove dead cells.
I stuck with the basics: Cetaphil Gentle Skin Cleanser and Daily Facial Moisturizer, as recommended by my dermatologist. I was also advised to stay away from any heavy exfoliation or products that were not made for sensitive skin.
You should take Isotretinoin at the same time every day with a meal, preferably a meal that has 20g or more of fat.