The only skin care product that can truly provide a slight tightening effect with regular use is Retin A, or Tretinoin. This is because Vitamin A helps speed up skin cell turnover, helping to boost collagen production.
Tretinoin Works Best as a Long-Term Treatment
Long-term studies of tretinoin tend to show the most dramatic results, with people experiencing significant reductions in the appearance of fine wrinkling, coarse wrinkling, skin laxity and other signs of photoaging.
How long does it take tretinoin to work? You may start noticing results from using tretinoin after 2-3 weeks but it usually takes 6 or more weeks to experience the full effects. Peer reviewed studies suggest you should consult your doctor if you're not seeing any results by week 12.
Engelman agrees: "Retinol is the most potent ingredient that helps build collagen and elastin, which leads to tighter, smoother skin."This mixture has the added bonus of hyaluronic acid, which "can smooth, firm, and tighten the appearance of the skin," Dr. Bowe says.
But tretinoin, another form of vitamin A, may be the most effective ingredient to firm the skin on your neck and face. Since 1984, multiple studies on animals and people show that tretinoin can firm your skin and increase collagen production to the point where sagging skin becomes less noticeable.
First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis.
"You can use tretinoin or [over-the-counter] retinols forever."
Tretinoin minimizes pore appearance by increasing cell turnover and boosting exfoliation, which clears debris in the pores and allows pores to shrink back to their normal size.
After 4-6 weeks, your skin will get used to tretinoin and will begin to be noticeably smoother and more even. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.
Retinoids are potent antioxidants that may boost collagen production. However, experts do not consider firming products to be effective overall, and their penetration of the skin may not be deep enough to help lift sagging skin.
Retinol and retinoids
There is data indicating that topical retinol combined with vitamin C is effective at replenishing skin elasticity. Prescription retinoids boost collagen production in the skin. They include tretinoin and retin-A.
If you stop using the medication or are inconsistent with your treatment, any improvements you see may disappear over time. Always use the product as prescribed by your healthcare provider (Rodan, 2016).
Generally, it is fine to use tretinoin every night, but you may not want to because of the initial side effects, especially when you first start. You should only use tretinoin as prescribed to avoid significant skin irritation, redness, and other side effects.
For the purposes of skin care, tretinoin can be thought of as a more concentrated version of retinol. This means that tretinoin is stronger than retinol. This difference in strength can help guide your decision-making when it comes to choosing a skin care product. Your skin is affected by more than what you put on it.
Does Retin-A (tretinoin) help reverse skin aging? Yes. Retin-A, whose active ingredient is tretinoin, has been shown to have positive effects on both the deeper collagen layers of your skin as well as the upper most layer that is comprised of skin cells.
One of the most common questions related to tretinoin is whether or not it's okay to exfoliate while you're using a topical tretinoin cream, gel or solution. Tretinoin is a reasonably powerful exfoliant that produces its own exfoliating effects, meaning there's usually no need to use any extra exfoliating products.
You may notice tretinoin starting to work within 2 to 3 weeks, but it can take 6 weeks or more to experience the full benefit. If you don't see improvement within 12 weeks, or if you have significant improvement and wonder if you should start using it less frequently, talk to your doctor.
Tretinoin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Tretinoin is classified as a "retinoid." (For more detail, see "How Tretinoin Works" section below).
Skin Discoloration
Tretinoin can fade spots on the face, evening out your skin tone and helping to hide the blotchy coloration that can affect many people's facial skin. In some cases, however, tretinoin can also cause small patches of skin to darken, producing noticeable skin discoloration.
Tretinoin for Hair Loss — The Science
In this study from the Journal of Investigative Dermatology on the effects of oral retin a — oral tretinoin — on human scalp hair follicles, research showed that exposure to retinoic acid induced premature hair follicle regression.
Since this is a long-term treatment, be prepared to use tretinoin for at least four months before you see the full benefits (Leyden, 2017). Lastly, be sure to use tretinoin consistently and as prescribed by your healthcare provider. The improvements in fine wrinkles disappear after you discontinue the drug.
Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying. If it accidentally gets on these areas, wash with water at once. Before applying tretinoin, wash the skin with a mild soap or cleanser and warm water by using the tips of your fingers.
After 6-9 months of regular Tretinoin use, you may notice firmer, less saggy skin around the eyes and jawline and fewer wrinkles. Be sure to use a good sunscreen every day (SPF 30 or higher) when using Retin A.
Commonly reported side effects of tretinoin include: pleural effusion, dyspnea, edema, fever, hypotension, leukocytosis, weight gain, headache, hypercholesterolemia, hypertriglyceridemia, increased liver enzymes, nausea, visual disturbance, and vomiting.