Topical vitamin A–based drugs called retinoids—the most used and most studied anti-aging compounds— may reduce fine lines and wrinkles. Tretinoin, under the brand name Retin-A, was the first retinoid.
1% tretinoin. Most anti-aging studies show that the best results usually come from moderate strength tretinoin creams, such as those that contain . 05% tretinoin.
Retin-A doesn`t improve appearance instantly. But within a month or two, dermatologists say, the drug visibly plumps up the skin, smoothes fine wrinkles and begins to reverse other, less visible, sun damage. Those effects can be fleeting, though.
When you first start using Retin-A, apply it every other night or every third night. The flaking and irritation are usually the worst in the first two weeks. As your skin adjusts to the medicine, you can apply it more frequently.
First, the answer is yes, retinol can make wrinkles worse, especially when you first start using it. What is happening is a drying effect, and one can get epidermal sliding from separation from the dermis.
Used regularly, retinol will also firm and smooth the skin under and around your eye.
Tretinoin Works Best as a Long-Term Treatment
Long-term studies of tretinoin tend to show the most dramatic results, with people experiencing significant reductions in the appearance of fine wrinkling, coarse wrinkling, skin laxity and other signs of photoaging.
However, it takes three to six months of regular use before improvements in wrinkles are apparent—and the best results take six to 12 months. Because retinoids can cause skin dryness and irritation, doctors often recommend using them only every other day at first and then gradually working up to nightly applications.
If you stop using the medication or are inconsistent with your treatment, any improvements you see may disappear over time. Always use the product as prescribed by your healthcare provider (Rodan, 2016).
Yes. It's perfectly safe to use a moisturizer with tretinoin. In fact, tretinoin without moisturizer is generally not recommended. Many dermatologists advise their patients to moisturize while using it to reduce their chance of developing dry, peeling skin.
Retinoids work best if you use them daily. Specifically, they should be used at night because some types are deactivated by light and air. It's important to start slowly and allow your skin time to adjust. Using too much too quickly can cause redness, dryness, and irritation.
Use just a pea-sized portion.
This is enough for your face. Dab a bit from this portion onto your forehead, cheeks, and chin, then smooth it around. Use another pea-sized portion for your neck or chest if you need to apply in those areas, too.
Later studies evaluated Tretinoin 0.05%. While both were equally effective over a one year period, Tretinoin 0.1% was able to achieve cosmetic improvement in 6 months while 0.05% required closer to 12 months. Finally, 0.025% was compared to 0.1% and it was found that both produced similar improvements in photoaging.
It helps with fine lines and wrinkles by increasing cell turnover, improving elasticity, and replenishing skin cells' collagen stores. While effective, tretinoin is not a quick fix—it can take several months of consistent use before you see any improvement in your fine lines and wrinkles.
"You can use tretinoin or [over-the-counter] retinols forever."
Commonly reported side effects of tretinoin include: pleural effusion, dyspnea, edema, fever, hypotension, leukocytosis, weight gain, headache, hypercholesterolemia, hypertriglyceridemia, increased liver enzymes, nausea, visual disturbance, and vomiting.
After 4-6 weeks, your skin will get used to tretinoin and will begin to be noticeably smoother and more even. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.
Doctors generally recommend using no more than a pea-size dab for the entire face. They advise using the product once every three nights (or once a week if skin feels irritated) for a couple of weeks, then every other night, eventually working up to every night if the skin can handle it.
Should you use retinol under your eyes? Yes, definitely. While it is true that retinol – a form of vitamin A – is a powerful ingredient and the skin under your eyes is delicate, there's no reason why you should miss out on the amazing benefits of retinol.
Tretinoin is a more potent retinoid than retinol and will show results faster. While these active ingredients both combat signs of photoaging (aka wrinkles, rough skin, uneven skin tone, and enlarged pores), tretinoin-based products like Night Shift are more effective for fighting acne.
But tretinoin, another form of vitamin A, may be the most effective ingredient to firm the skin on your neck and face. Since 1984, multiple studies on animals and people show that tretinoin can firm your skin and increase collagen production to the point where sagging skin becomes less noticeable.
Retinoids are potent antioxidants that may boost collagen production. However, experts do not consider firming products to be effective overall, and their penetration of the skin may not be deep enough to help lift sagging skin.
Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying.