Does niacinamide conflict with hyaluronic acid?

Author: Dr. Kenyon Kris DVM  |  Last update: Monday, July 28, 2025

You can pair niacinamide and hyaluronic acid together as part of your skincare routine, as both are water-based ingredients. A hyaluronic acid product like Hyalu B5 serum should be applied first to hydrate and replenish the skin.

Can you use hyaluronic acid and niacinamide together?

Hyaluronic acid and niacinamide are actually quite complementary. Hyaluronic acid helps hydrate and plump the skin, while niacinamide supports skin barrier function, reduces excess oil, and helps brighten the skin tone. When used together, they provide a balanced approach to hydration and healthy-looking skin.

What not to mix with niacinamide and hyaluronic acid?

Niacinamide can be used with many active ingredients in your skincare routine including: Retinol, Vitamin C, Hyaluronic acid, AHAs, and BHAs. But never mix it with any product which has Glycolic Acid in it and take a gape of minimum 30 minutes after applying niacinamide.

What should I never mix with hyaluronic acid?

What Not to Mix with Hyaluronic Acid: Expert Advice for Your Skincare Routine
  • Retinol and Hyaluronic Acid: A Powerful Combination. ...
  • However, there are certain ingredients that should not be mixed with hyaluronic acid: ...
  • Step 1: Cleansing. ...
  • Step 2: Toner/Mist. ...
  • Step 3: Antioxidant Serum. ...
  • Step 4: Moisturizer. ...
  • Step 5: Sunscreen.

Can I mix niacinamide powder with hyaluronic acid?

There are a number of other options you can mix the 100% Niacinamide Powder with including Hyaluronic Acid 2% + B5, “Buffet” + Copper Peptides 1%, Matrixyl 10% + HA, and Argireline Solution 10% to name a few! Mix with 2 drops of vitamin E oil and lotion.

HOW TO USE THE ORDINARY HYALURONIC ACID AND NIACINAMIDE | Demo | How to layer the ordinary

Which goes first, hyaluronic acid or niacinamide?

When used together, always go with applying hyaluronic acid first, followed by Niacinamide. By following this, you would be able to attract plenty of hydration first. After that, apply Niacinamide to help regulate sebum production and help with the minimization of pores.

What is the best combination with niacinamide?

Niacinamide + salicylic acid is what you need in your skincare routine. Salicylic acid is best known for its deep-cleansing properties and deep-penetrating action to unclog pores and slough off dead and dry skin. The antibacterial and anti-inflammatory properties of salicylic acid help clear away pustules and papules.

What is the best pair for hyaluronic acid?

As a pair, vitamin C and hyaluronic acid benefit the skin in numerous ways, though the duo is most often used to help combat the visible signs of aging.

Is there a downside to hyaluronic acid?

The most common adverse effects associated with hyaluronic acid filler are pain, bruising, redness, itching, and swelling. These side effects are self-limited and typically last no more than seven days.

What does niacinamide do for skin?

Niacinamide helps strengthen the skin's lipid barrier, which is crucial for maintaining moisture and protecting against environmental aggressors. By supporting the skin's natural content of ceramides and fatty acids, niacinamide helps to prevent transepidermal water loss, keeping the skin hydrated and resilient.

What reacts badly with niacinamide?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

What should be avoided with niacinamide?

Don't use vitamin C: Niacinamide and vitamin C can cause skin irritation and discoloration when used together, so it's best to use them at different times of the day. Don't overuse: While niacinamide is generally well-tolerated, overusing it can cause redness and irritation, especially in people with sensitive skin.

When to use niacinamide, morning or night?

Should You Use Niacinamide In the AM Or PM? Niacinamide is recommended to be applied up to two times per day. Given this advice, it is typically applied once in the AM and again in the PM before bed. Unlike retinol, niacinamide doesn't increase skin sensitivity and higher chance of reactions from the sun.

Can I use niacinamide every day?

It's an ingredient found in a number of moisturizing skin-care products as well as in certain foods and supplements like multivitamins. Can you use niacinamide every day? Yes. In fact, you can use niacinamide-containing topical products in the morning and night because it's generally a gentle ingredient.

Is it better to use hyaluronic acid in the morning or at night?

If you have dehydrated skin, use hyaluronic acid serum both in the morning and at night. In the morning, it might help hydrate your skin and prepare it for the day ahead. At night, it might help repair and rejuvenate your skin while you sleep. Be sure to follow up with a moisturizer to lock in the hydration.

Is niacinamide good for inflammation?

Niacinamide has been shown to ease inflammation, which can help calm redness due to conditions like acne, rosacea and eczema. It can also soothe irritation caused by strong exfoliants like retinol or glycolic acid that remove dead cells from the surface of your skin.

Is hyaluronic acid hard on the liver?

10. Is Hyaluronic Acid Bad For Your Liver? In the case of patients with liver diseases, it is advised to avoid using HA as the increased levels of HA in the bloodstream can cause thrombosis. Hence, user discretion and medical supervision are advised.

What happens if you use hyaluronic acid everyday?

What does hyaluronic acid do for skin? Long-term use of hyaluronic acid serum on your skin or in a supplement taken by mouth can improve overall skin health. It's also great for helping improve overall skin flexibility and elasticity (meaning it makes your skin more stretchy and soft).

Which face serum is best?

  • Vitamin C Daily Glow Face Serum With Vitamin C & Turmeric for Radiant Skin - 30 ml. ...
  • Skin Correct Face Serum with Niacinamide and Ginger Extract for Acne Marks and Scars - 30 ml. ...
  • Vitamin C Daily Glow Face Serum 10 ml. ...
  • Rice Water Dewy Active Serum With Rice Water & 10% Niacinamide For Glass Skin - 50 ml.

What cannot be mixed with hyaluronic acid?

For instance, Alpha Hydroxy Acids (AHAs), such as Lactic Acid and Glycolic Acid, and Synthetic Retinol are a pair that can easily cause irritation.

Can you use too much niacinamide?

“Overusing niacinamide or using high percentage products can cause irritation and breakouts,” she adds. Additionally, if you're just starting to add niacinamide into your skin care routine, you'll want to start slow.

How long to wait between hyaluronic acid and niacinamide?

Hyaluronic acid serums are usually lightweight and absorb quickly, so you don't need to wait longer than a minute or two to apply a niacinamide cream. If both products are thick or sticky, wait until the skin absorbs the first layer to avoid mixing and diluting the products.

What cannot be mixed with niacinamide?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

Should I use hyaluronic acid or niacinamide first?

That said, for the best results, we suggest using hyaluronic acid first, followed by niacinamide. The order here matters because, as a rule of thumb, you should always go in order of consistency. Start with the products and ingredients with a lighter consistency and work up to a thicker consistency.

What are the side effects of using niacinamide on your face?

Niacinamide is possibly safe when taken in doses up to 900-1500 mg daily. It might cause side effects such as stomach upset, gas, dizziness, headache, and rash. When applied to the skin: Niacinamide is possibly safe. Niacinamide cream might cause mild burning, itching, or redness.

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