Ophthamologists and current studies have indicated that Latisse for cosmetic uses might cause PAP - a sinking in of the eyes with long term use and loss of fat and fat cells around the eyes.
Will I have significant fat loss occur around the orbital/eye socket area, resulting in a depression? No. This myth originates with the eye drop version of Bimatoprost, which was applied directly into the eye. There has been no recorded evidence of this occurring when used in its Latisse variation.
Fat atrophy caused by Latisse is appears to be reversible. If you see fat shrinkage that you find unattractive, you can stop using the Latisse and the process would be anticipated to gradually reverse. (Note use of "appears" and "anticipated").
The periorbital fat atrophy is most apparent with uniocular use and both doctors and patients need to be aware of this side effect before commencing treatment. The effects, however, appear to be reversible with treatment cessation.
There is no scientific evidence that shows that GrandeLASH-MD eyelash serum can cause orbital fat loss. That side effect is associated with prescription drug eyelash serums.
Bringing the fullness back into the orbit can be performed with injections of hyaluronic acid-based fillers such as Restylane or Juvederm or with fat grafting. Restylane and Juvederm offer a temporary correction as most fillers suitable for the orbit are resorbed by the body in 6 to 9 months.
Exposure to the prostaglandin affects their metabolism, causing them to shrink. The shrinkage of the fat cells surrounding the eye causes enophthalmos—the eye becomes more sunken-in. The result is a deepening of the superior eye lid sulcus, while periorbital fat tissue seems to melt away.
Structural Fat Grafting for Upper Eyelids, Eyebrows, and Temples. Structural fat grafting is a procedure that harvests fat from an area or areas of your body and places it elsewhere. The procedure can be used on the upper eyelids, eyebrows, and temples to provide a more youthful appearance.
The loss of volume in the upper orbit is seen with all of the prostaglandin glaucoma drops but the effect is greatest for bimatoprost, the medication in Latisse. Studies suggest that as many as 50 to 60% of individual using prostaglandin glaucoma drops will develop deepening of the upper eyelid sulcus.
If you stop using LATISSE® at any time, your eyelashes will return to their previous appearance over several weeks to months. Set your sights on growth. As the treatment progresses, you'll first begin to see changes in length. Then, gradually, you'll notice more thickness and darkness in your lashes.
“It's possible that loss of fat around the eye may be permanent in some special cases, but for most cases it'll resolve gradually when you stop taking Latisse,” says Dr. Schwartz.
Good candidates for eyelid rejuvenation with Latisse are:
Those with excessive upper eyelid skin with hooding.
Can Latisse Be Used on Lower Lashes? Dermatologists do not recommend using Latisse on lower lashes. Applying Latisse to areas beyond the upper lash line may cause excess hair growth in unwanted areas. For best results, Latisse should only be applied to your upper lash line.
Possible side effects. The most common side effects after using LATISSE® are an itching sensation in the eyes and/or eye redness, which were reported in approximately 4% of clinical trial patients. LATISSE® solution may cause other less common side effects which typically occur close to where LATISSE® is applied.
Many people have some degree of fat loss or lid skin tightening around their eyes after using Latisse for eyelash growth. Most find it unnoticeable or like the appearance, some decide to stop the medication, others keep going and have a little filler injected to get the look they want.
It is not possible to cure ptosis unless the cause is a Botox injection, but treatment can easily manage the condition.
Conclusion: Bimatoprost may lead to an alteration of the eyelid with deepening of the lid sulcus and may also be responsible for an iatrogenic orbital fat atrophy. A possible mechanism of action might be the induction of apoptosis of orbital fibroblasts with a remodelling of the extracellular matrix.
Drooping of the eyelid is called ptosis. Ptosis may result from damage to the nerve that controls the muscles of the eyelid, problems with the muscle strength (as in myasthenia gravis), or from swelling of the lid.
A fat transfer is a natural type of dermal filler. Your healthcare provider uses liposuction to draw fat cells out of your belly, hips or thighs. They purify the cells and inject them into the skin below your lower eyelids. This cosmetic procedure can make your eyes look less tired and make you appear younger.
Answer: Orbital fat loss
Repairing the ptosis will reduce the aperture of the eyelid opening and help from raising the eyebrows to compensate for the ptosis. Best to seek out an oculoplastic surgeon well versed in ptosis repair and a possible small amount of fat grafting to the upper lids.
Answer: Eyelid fat is part of the eye socket and supports the eye and surrounding structures. This fat differs from the rest of your body fat and typically does not change with weight gain or weight loss.
The most common treatment for under eye hollowness is the use of a cosmetic hyaluronic acid filler such as Restylane or Juvederm to restore volume under the eyes. Hyaluronic acid occurs naturally in the body, so these fillers are generally hypoallergenic.