Hyaluronidase injections are highly targeted, so they will dissolve hyaluronic acid filler before they dissolve any natural hyaluronic acid. Our skin and tissues are not broken down by injected hyaluronidase, however.
A published journal article states that higher doses [of hy'dase] can lead to damage of native extracellular matrix glycosaminoclycans, leaving a gaunt appearance with poor skin texture (Figure 4). Patients are increasingly presenting with hyaluronidase-related damage, which is often untreatable.
Collagenase in combination with hyaluronidase was quite efficient at destroying the connective tissue matrix, although elastic tissue appeared to be completely spared. Collagenase alone at higher doses degraded collagen, but hyaluronidase had little effect on connective tissue architecture.
If injected incorrectly, the Hyaluronidase dissolver can break down your own skin tissue, and cause caved in cheeks and loose skin.
Hyaluronidase has also been shown to diffuse into the lumen of blood vessels even when injected external to it; for potential cases of necrosis due to intravascular deposition of hyaluronic acid, it is not essential to inject directly into the vessel—injection into the surrounding area is also likely to result in ...
Hyaluronidase was also used to dissolve the suspected filler in a second patient, and the third patient has elected to continue with observation. Conclusions: Filler migration is one of the potential complications associated with the injection of soft tissue fillers.
Injection of hyaluronidase into the fibrotic scar lesion was effective in improving the pliability, height, and pigmentation of the fibrotic lesions by breaking down the ground substance of the connective tissue [1]. The VSS is used primarily as an index of scar after external wound.
Hyaluronidase doesn't spread so you won't have a problem with having it injected into your top lip while avoiding the marionette lines, which you do like.
You can have hyaluronidase as many times as needed. The most I usually do is 3x spread about a week apart. I never inject as much as your injector though.
Avoid any heat-inducing activities for 24 hours such as strenuous exercise, spas, saunas and hot showers.
Are dissolving lip fillers safe? Because, like the fillers themselves, this treatment uses a naturally occurring bodily material, this treatment is very safe. However, there is a small risk of an allergic reaction to the hyaluronidase injected.
Hyaluronidase cannot destroy other natural tissue such as collagen, however, it can break down natural hyaluronic acid at the same time as denaturing the HA filler product.
Hyaluronidase works primarily on hyaluronic acid but to a lesser degree on other mucopolysaccharides in connective tissue such as glycosaminoglycans in the skin's extracellular matrix. It does not affect fibroblast activity or collagen in the skin itself (collagenase is an enzyme that degrades collagen).
An enzyme that breaks down a substance in the body called hyaluronic acid. Hyaluronic acid is found throughout the body in connective tissue, skin, and fluids in the joints and inside the eye. It causes fluids to have a jelly-like thickness, which can help moisten and protect tissues and joints.
Hyaluronidase has immediate effect and a half-life of two minutes with duration of action of 24 to 48 hours.
After a hyaluronidase injection, the skin will typically restore its hyaluronic acid levels within a few days or, in rare cases, over the course of a few weeks.
Hyaluronidase most certainly will not cause nerve damage. Now it is possible that the needle used to inject the hyaluronidase can hit or pierce a nerve which can cause a bruised nerve and temporary problems.
Due to the spreading effect of hyaluronidase, treatment should not be performed in an area where botulinum toxin has been performed within the last 48 hours or an area of skin infection unless there is a vascular occlusion and the risks outweigh the benefits.
The Hyaluronidase enzyme speeds up a break down of hyaluronic acid (Lip filler). It works very quickly though it can have side effects and these include: A probable minimal and temporary effect on your own natural hyaluronic acid, which then re-grows after the injection.
Most patients experience minimal recovery time following an injection of hyaluronidase. Mild swelling, redness, and discomfort at the injection site usually resolve within 10 days. In some cases, there are some minimal limitations on strenuous activity following the procedure.
Answer: Hyaluronidase should be massaged after injection
Two, it helps the unwanted HA break down and resorb. You should know that hyaluronidase works very quickly, often times within a 1-3 day span, so if you don't see resolution, you should check back with your injectionist.
Conclusions: Our data suggest that the hyaluronidase loses its effect in dermis and subcutaneous tissue within 3-6 hours after the injection and successful engraftment of reinjected HA filler can be accomplished 6 hours after the injection.
Answer: DIfferent fillers require different doses of Hyaluronidase. Juvederm and more particalarly juvderm plus require higher doses of hyaluronidase to dissolve compared to other fillers. If the lumps are truly filler it is most likely a dosage issue.
Most hyaluronic acid fillers used in the lips, jawline, and cheeks, including Juvederm and Restylane, metabolize after 6 months to a year. Sculptra can continue to provide results in the face for up to two years.