These patients report that hyaluronidase injections into the original treatment area (e.g. just the lips or just the cheekbones) has caused volume loss, sagging, and textural changes in all facial regions (e.g. one patient had the Restylane in her lips dissolved and attributes her under eye hollows to that treatment).
Although Hyaluronidase is a pesky enzyme that breaks down collagen in the skin. It destroys the natural hyaluronic acid created in the body, therefore disabling it from binding collagen and elastin molecules. This prevents the formation of new collagen and elastin and causes premature wrinkling and sagging.
After a hyaluronidase injection, the skin will typically restore its hyaluronic acid levels within a few days or, in rare cases, over the course of a few weeks.
Hyaluronidase works primarily on hyaluronic acid but to a lesser degree on other mucopolysaccharides in connective tissue such as glycosaminoglycans in the skin's extracellular matrix. It does not affect fibroblast activity or collagen in the skin itself (collagenase is an enzyme that degrades collagen).
Hyaluronidase injections are highly targeted, so they will dissolve hyaluronic acid filler before they dissolve any natural hyaluronic acid. Our skin and tissues are not broken down by injected hyaluronidase, however.
Hyaluronidase was also used to dissolve the suspected filler in a second patient, and the third patient has elected to continue with observation. Conclusions: Filler migration is one of the potential complications associated with the injection of soft tissue fillers.
A published journal article states that higher doses [of hy'dase] can lead to damage of native extracellular matrix glycosaminoclycans, leaving a gaunt appearance with poor skin texture (Figure 4). Patients are increasingly presenting with hyaluronidase-related damage, which is often untreatable.
Are dissolving lip fillers safe? Because, like the fillers themselves, this treatment uses a naturally occurring bodily material, this treatment is very safe. However, there is a small risk of an allergic reaction to the hyaluronidase injected.
Hyaluronidase doesn't spread so you won't have a problem with having it injected into your top lip while avoiding the marionette lines, which you do like.
While it is largely unreported on in the press and in medical literature, many people suffer from injuries and other problems after having Hyaluronidase injections to dissolve lip filler gone wrong.
Avoid any heat-inducing activities for 24 hours such as strenuous exercise, spas, saunas and hot showers.
You can have hyaluronidase as many times as needed. The most I usually do is 3x spread about a week apart. I never inject as much as your injector though.
Hyaluronidase has immediate effect and a half-life of two minutes with duration of action of 24 to 48 hours.
Conclusion. HYAL is a bioactive enzyme that exerts multiple effects on the HA-metabolism as well as on the structural cells of the skin. Our results indicate that HYAL promotes wound healing and exerts a dose-dependent induction of HA-synthesis in structural cells of the skin.
In most cases filler will eventually dissolve and you should be able to achieve your natural features.
HOW LONG UNTIL I SEE THE EFFECTS OF FILLER DISSOLVING? Hyaluronidase has immediate effect and a half-life of two minutes with duration of action of 24 to 48 hours. Once we start the process of injecting the hyaluronidase, the dermal filler in that area starts to break down and soften immediately.
Lots of patients have their filler dissolved, often to erase the previous work and get back to a blank canvas. Once the filler is completely dissolved and swelling has subsided – usually after about two weeks – it is safe to have filler injected again in the same area.
Answer: How long after dissolving filler can I get reinjected? Most of the dissolving when using hyaluronidase takes place in the first 15-30 minutes. It can continue to work for 3 days. After 3 days, there is no active enzyme and further injections can be performed.
Hyaluronidase has also been shown to diffuse into the lumen of blood vessels even when injected external to it; for potential cases of necrosis due to intravascular deposition of hyaluronic acid, it is not essential to inject directly into the vessel—injection into the surrounding area is also likely to result in ...
Skin necrosis is considered the most serious complication of hyaluronic acid dermal filler injection procedures.
Conclusion: In this study, sodium bicarbonate buffered 2% lidocaine was found to be a safe and effective local anaesthetic, with reduced time of onset, and improved quality of both anaesthesia and akinesia. Sodium bicarbonate (7.5%) may be used as an alternative to hyaluronidase in ocular anaesthesia.
Conclusions: Our data suggest that the hyaluronidase loses its effect in dermis and subcutaneous tissue within 3-6 hours after the injection and successful engraftment of reinjected HA filler can be accomplished 6 hours after the injection.
Answer: DIfferent fillers require different doses of Hyaluronidase. Juvederm and more particalarly juvderm plus require higher doses of hyaluronidase to dissolve compared to other fillers. If the lumps are truly filler it is most likely a dosage issue.
"In cases of undereye filler, migration is seen as bumps in the lower eyelid and/or upper cheeks areas underneath the eyes." Dr.