Yes. It's perfectly safe to use a moisturizer with tretinoin. In fact, tretinoin without moisturizer is generally not recommended. Many dermatologists advise their patients to moisturize while using it to reduce their chance of developing dry, peeling skin.
Safety of combining skin care products
While highly effective, the possible side effects of skin discomfort may make using tretinoin difficult. However, a 2019 study notes that using tretinoin with a moisturizer can help reduce its potential irritation and drying effects.
The routine order for applying retinoid
To help your retinoid work better, some dermatologists recommend applying it directly after cleansing before any other treatment serum or moisturizer.
L'Oréal Paris RevitaLift Night Serum with Pure Retinol
Goldenberg's go-to recommendation for timing between serums and moisturizers is about one minute. This wait has the same reasoning: Sixty seconds — give or take — gives each product a moment to delve into your pores.
Just make sure you choose products without synthetic fragrances to keep irritation at bay. When starting out, apply moisturizer directly after applying tretinoin to minimize potential irritation. As your skin adjusts, you can leave tretinoin on for about 20 minutes before following up with a moisturizer.
A formula with retinol, like the L'Oréal Paris Revitalift Triple Power Eye Treatment, should be applied after your serums and before moisturizer due to its consistency.
To use retinol before a moisturizer, wash the face and when completely dry, apply a pea-size amount of retinol. Retinol should not be used on damp skin because the skin will absorb more than required and cause irritation. Finish with a moisturizer to hydrate the skin and reduce the risk of irritation.
Generally, it is fine to use tretinoin every night, but you may not want to because of the initial side effects, especially when you first start. You should only use tretinoin as prescribed to avoid significant skin irritation, redness, and other side effects.
Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying. If it accidentally gets on these areas, wash with water at once. Before applying tretinoin, wash the skin with a mild soap or cleanser and warm water by using the tips of your fingers.
Retin-A Micro is a costlier, time-released version that is available only as a gel. It is less likely to cause irritation and dryness and can be applied immediately after cleansing. However, it may not be as effective as Retin-A cream for anti-aging treatments and may be better suited than creams for oilier skin types.
Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Avoid using other medications on the areas you treat with tretinoin topical unless your doctor tells you to.
Unless your doctor tells you otherwise, it is especially important to avoid using the following skin products on the same area as tretinoin: Any other topical acne product or skin product containing a peeling agent (eg, benzoyl peroxide, resorcinol, salicylic acid, or sulfur).
It might take two or three weeks of using Retin-A (treitinoin) to see any benefits. However, in some cases, it may take six weeks or more.
Retin-A Micro is available in four strengths: 0.1%, 0.08%, 0.06% and 0.04%.
Uses for Retin-A
One of the tretinoin creams is used to treat fine wrinkles, dark spots, or rough skin on the face caused by the damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and slowing down the way the body removes skin cells that may have been harmed by the sun.
Use just a pea-sized portion.
This is enough for your face. Dab a bit from this portion onto your forehead, cheeks, and chin, then smooth it around. Use another pea-sized portion for your neck or chest if you need to apply in those areas, too.
The problem is, retinol can be irritating when applied straight to the lips (so keep your prescription-strength cream off your mouth for the time being). But Verso's formula contains a gentle derivative, called retinol 8, which can reduce the appearance of fine lines around the mouth overtime.
In the morning, wash your face with a mild facial scrub or rough washcloth. This will help reduce the noticeable flaking. After washing, apply a good water-based moisturizer. The moisturizer will make the drying effect of the medicine more tolerable.
Apply Tretinoin Cream or Gel at Night
The recommended time to apply tretinoin cream or gel to your face is at night, shortly before you go to bed. This allows the tretinoin to be fully absorbed by your facial skin without any risk of sunlight affecting your skin.
After 4-6 weeks, your skin will get used to tretinoin and will begin to be noticeably smoother and more even. A lot of the initial irritation will settle down and true “retinization” of your skin is in full force.
Tretinoin Works Best as a Long-Term Treatment
Long-term studies of tretinoin tend to show the most dramatic results, with people experiencing significant reductions in the appearance of fine wrinkling, coarse wrinkling, skin laxity and other signs of photoaging.
"You can use tretinoin or [over-the-counter] retinols forever."