Can I pair niacinamide with hyaluronic acid?

Author: Dr. Tyson Grady V  |  Last update: Wednesday, May 21, 2025

Hyaluronic acid and Niacinamide are a great pair as both are water-based treatments. When used together, always go with applying hyaluronic acid first, followed by Niacinamide. By following this, you would be able to attract plenty of hydration first.

Can hyaluronic acid and niacinamide be used together?

Pairing Hyaluronic acid with niacinamide is good because they both are water-based ingredients that combine to make the perfect regime for all skin types. Considering the nature of these acids, their chances of evoking a skin reaction are slim.

What can you not mix with niacinamide?

Niacinamide generally works well with most products, but it's best not to combine it with vitamin C (ascorbic acid) in the same routine as it can cause irritation. Additionally, avoid using it with strong exfoliants or retinoids in high concentrations to prevent skin sensitivity. For more, check out my Quora Profile.

Is it better to use hyaluronic acid or niacinamide at night?

Finally, you can use the ingredients at different times. Apply hyaluronic acid in the morning and niacinamide at night. Thoroughly cleanse the skin before applying other products and remember to use broad-spectrum sunscreen as the final step in your daytime routine.

What to not mix with hyaluronic acid?

“Hyaluronic acid plays well with most ingredients, while caution must be taken when using retinol in combination with alpha hydroxy and beta hydroxy acids, benzoyl peroxide, and some types of vitamin C.” Linkner echoes the tip about avoiding vitamin C.

the ordinary niacinamide and hyaluronic acid 1 MONTH review (with BEFORE/AFTER)

Which is the best combination with hyaluronic acid?

Hyaluronic acid and vitamin C is one of the best skincare pair that ensures superior skin health. These two ingredients compliment and complete each other when it comes to hydrating skin, and repairing signs of ageing.

Which two serums should not be mixed?

Skincare ingredients not to mix
  • Retinoids or retinol and benzoyl peroxide. ...
  • Retinoids or retinol and vitamin C. ...
  • Retinoids or retinol and salicylic acid. ...
  • Retinoid or retinol and AHAs/BHAs. ...
  • Vitamin C and AHAs/BHAs. ...
  • Vitamin C and benzoyl peroxide. ...
  • Niacinamide and AHAs / BHAs. ...
  • Benzoyl peroxide and hydroquinone.

What goes first, hyaluronic acid or niacinamide?

When used together, always go with applying hyaluronic acid first, followed by Niacinamide. By following this, you would be able to attract plenty of hydration first. After that, apply Niacinamide to help regulate sebum production and help with the minimization of pores.

When not to use niacinamide?

Gallbladder disease: Niacinamide might make gallbladder disease worse. Kidney dialysis: Taking niacinamide seems to increase the risk of low platelet levels in people with kidney failure who are on dialysis. Stomach or intestinal ulcers: Niacinamide might make ulcers worse.

What is better for aging skin, niacinamide or hyaluronic acid?

For those struggling with acne, inflammation, or excess oil production, niacinamide may be the better option. On the other hand, if your primary concern is dryness, dehydration, or aging skin, hyaluronic acid could be the way to go.

What cancels out niacinamide?

DON'T MIX: AHA/BHA and niacinamide

Niacinamide is used to treat hyperpigmentation and reduce fine lines and wrinkles, while alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs) are chemical exfoliants. To understand why niacinamide shouldn't be mixed with AHAs and BHAs, you need to consider pH.

What reacts badly with niacinamide?

Niacinamide works well with other skincare ingredients, including retinol and hyaluronic acid. However, some ingredients, like vitamin C, may interact negatively with niacinamide. Therefore, it's recommended to use products containing these ingredients at different times of the day or on alternate days.

What is the best combination with niacinamide?

Niacinamide + salicylic acid is what you need in your skincare routine. Salicylic acid is best known for its deep-cleansing properties and deep-penetrating action to unclog pores and slough off dead and dry skin. The antibacterial and anti-inflammatory properties of salicylic acid help clear away pustules and papules.

Can I use niacinamide every day?

It's an ingredient found in a number of moisturizing skin-care products as well as in certain foods and supplements like multivitamins. Can you use niacinamide every day? Yes. In fact, you can use niacinamide-containing topical products in the morning and night because it's generally a gentle ingredient.

Can I use niacinamide with hyaluronic acid and retinol?

You can use retinol with niacinamide and hyaluronic acid. Retinol tends to cause dryness and irritation, while hyaluronic acid and niacinamide hydrate the skin and maintain your skin's function as a protective barrier. Do not combine retinol with AHAs, BHAs, or Vitamin C.

Should I use hyaluronic acid in the morning or night?

If you have dehydrated skin, use hyaluronic acid serum both in the morning and at night. In the morning, it might help hydrate your skin and prepare it for the day ahead. At night, it might help repair and rejuvenate your skin while you sleep. Be sure to follow up with a moisturizer to lock in the hydration.

Is 10% niacinamide too much for beginners?

Now, most people can tolerate niacinamide well even at 10% twice daily. But if you have a mysterious skin rash or unexplained irritation, it could be time to take a closer look at your niacinamide levels.

What are the disadvantages of niacinamide on face?

What are the side effects of Niacinamide? Topical application is completely safe and may not cause any skin problems for a healthy person. People with sensitive skin may face mild redness, itching, or a burning sensation. Stomach upset.

What products Cannot be used with niacinamide?

Don't mix: Vitamin C should not be used with retinol products as this can cause irritation. Additionally, vitamin C should not be mixed with niacinamide since the effectiveness of vitamin C will be decreased.

Should I use niacinamide in the morning or night?

4. When should I apply niacinamide? Niacinamide can also be used morning and/or night, but as it's an antioxidant and can help to control oil and treat breakouts (invisibly!), it is well-suited to a morning routine (just avoid layering it with vitamin C as the two can make each other unstable).

What ordinary products should I not use together?

Which The Ordinary products should not be used together? Many people are divided over which ingredients can and can't be layered together, however 'best practice' advice from dermatologists is not to layer acids with each other, or with vitamin C, or retinoids.

Do you wait for hyaluronic acid to dry before moisturizer?

Always make sure to follow with a moisturizer, this is a skincare must in general, but especially when using Hyaluronic Acid Serum because it locks the moisture in. But it's important to wait 30-60 seconds for the serum to absorb before following with other products.

What not to pair with hyaluronic acid?

However, there are certain ingredients that should not be mixed with hyaluronic acid:
  • AHAs and BHAs: AHAs (alpha hydroxy acids) and BHAs (beta hydroxy acids) are chemical exfoliants that can help improve skin texture and unclog pores. ...
  • Benzoyl Peroxide: Benzoyl peroxide is a common ingredient found in acne treatments.

Can I use 3 serums at the same time?

A general rule of thumb is to layer 2-3 serums. This ensures skin doesn't become overwhelmed and gives each formula the space to absorb properly. However – as mentioned above, all skin is unique. Some skin concerns could benefit from up to 5 serums, if heightened moisture, protection and firming for example is needed.

When to use hyaluronic acid and niacinamide?

Use/layer hyaluronic acid in your morning skincare routine to keep your skin hydrated the entire day and niacinamide at night to fix indications of aging, for example, wrinkles, fine lines, dark spots, and enlarged pores.

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