Are there any bad side effects to hyaluronic acid?

Author: Mr. Antwon Satterfield PhD  |  Last update: Saturday, November 1, 2025

Although hyaluronic acid-based dermal fillers have a low overall incidence of long term side effects, occasional adverse outcomes, ranging from chronic lymphoplasmacytic inflammatory reactions to classic foreign body-type granulomatous reactions have been documented.

Does hyaluronic acid have negative effects?

The most common adverse effects associated with hyaluronic acid filler are pain, bruising, redness, itching, and swelling. These side effects are self-limited and typically last no more than seven days.

Who should avoid hyaluronic acid?

However, people who have a history of severe allergic reactions, such as anaphylaxis, should be cautious when using hyaluronic acid. Its effects during pregnancy and while breastfeeding remain unknown, so women may want to avoid taking hyaluronic acid supplements during these times.

What happens if you use hyaluronic acid everyday?

What does hyaluronic acid do for skin? Long-term use of hyaluronic acid serum on your skin or in a supplement taken by mouth can improve overall skin health. It's also great for helping improve overall skin flexibility and elasticity (meaning it makes your skin more stretchy and soft).

Is hyaluronic acid hard on your liver?

10. Is Hyaluronic Acid Bad For Your Liver? In the case of patients with liver diseases, it is advised to avoid using HA as the increased levels of HA in the bloodstream can cause thrombosis. Hence, user discretion and medical supervision are advised.

Does Hyaluronic Acid cause Cancer?! What does the Evidence say?

Does hyaluronic acid affect the kidneys?

Over the past 15 years, HA has been observed to induce varying effects in kidney injury and disease that largely depend on the study model but are considerably influenced by its MW. For example, Ito et al. showed that HMW-HA bound to CD44 promotes proximal tubular cell (PTC) migration in vitro via MAPK activation [41].

What are the complications of hyaluronic acid?

The most common complications are injection site reactions, including edema, pain, erythema, itching, and ecchymosis [14]. Other reported AEs are hypersensitivity reactions, infections, Tyndall effect, and surface irregularities and nodules [15-18].

When should you not use hyaluronic acid?

Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don't use hyaluronic acid on your skin.

What does hyaluronic acid do to hair?

Hyaluronic Acid helps to seal the cuticle, locking in moisture and taming that unwanted frizz. Address Scalp Dryness - Scalp care is the key to overall health hair. As mentioned above, Hyaluronic Acid is an hydrating ingredient that does not only hydrate the hair, but the scalp too!

What is the best hyaluronic acid for mature skin?

We chose OSEA Hyaluronic Sea Serum as the best for mature skin because of its impressive ability to deliver overnight hydration, leaving our skin looking fresh, plump, and radiant by morning. Mature skin often requires intense moisture to maintain elasticity and minimize fine lines, and this serum excels at both.

What Cannot be paired with hyaluronic acid?

Niacinamide and Salicylic Acid: Niacinamide is a popular skincare ingredient that can help minimize pores and improve skin texture. Salicylic acid, on the other hand, is often used to treat acne. While both ingredients have their own benefits, using them together with hyaluronic acid may cause irritation or dryness.

What is the new injection for knee pain?

Arthrosamid is a permanent injectable hydrogel that provides in most patients an effective long-term pain relief for knee osteoarthritis without the need for surgery. The treatment uses intra-articular polyacrylamide hydrogel or iPAAG.

Do doctors recommend hyaluronic acid?

Your doctor may recommend HA shots if you've tried and failed to get relief from conservative non-drug options, like weight loss, exercise and physical therapy – the safest and most effective ways to improve OA pain and function – or from nonsteroidal anti-inflammatory drugs (NSAIDs), which can cause side effects and ...

What are the cons of hyaluronic acid serum?

Are there any side effects to using hyaluronic acid?
  • Bruising.
  • Sore injection site.
  • Swelling.
  • Formation of tiny, generally temporary bumps.

Can you overdo it with hyaluronic acid?

While hyaluronic acid is a great hydrator, overusing it can lead to dehydrated skin. This happens because hyaluronic acid can only attract and retain a limited amount of moisture, and using too much can cause it to pull moisture from deeper layers of the skin.

Which face serum is best?

  • Vitamin C Daily Glow Face Serum With Vitamin C & Turmeric for Radiant Skin - 30 ml. ...
  • Skin Correct Face Serum with Niacinamide and Ginger Extract for Acne Marks and Scars - 30 ml. ...
  • Vitamin C Daily Glow Face Serum 10 ml. ...
  • Rice Water Dewy Active Serum With Rice Water & 10% Niacinamide For Glass Skin - 50 ml.

Can hyaluronic acid cause facial hair growth?

Also, hyaluronic acid in hair can help the hair follicles lock in moisture, banish frizz, and potentially add volume to your mane. If you have trouble with dry skin on your scalp the acid can also help moisturize any flaky and dry areas and in combination with other ingredients it can help to stimulate beard growth .

What acid is best for hair growth?

Here are 5 acids for hair growth:
  1. Hyaluronic acid (HA) Hyaluronic acid is known to help your skin look and feel glowing, hydrated, soft and supple. ...
  2. Salicylic acid. Salicylic acid is a type of beta hydroxy acid (BHAs) that can be found in serums and toners. ...
  3. Lactic acid. ...
  4. Lysine. ...
  5. Glycolic acid.

Can I leave hyaluronic acid on my scalp?

Depending on the hyaluronic acid hair product you are using, time will vary. Some products will require that you leave them in your hair for only a few minutes before rinsing out. Others can be applied and left in. It's best to check product instructions.

What happens when you stop using hyaluronic acid?

Potential for Increased Dryness and Flakiness

If you have dry or sensitive skin, stopping the use of an HA serum can exacerbate these conditions. HA serums help to maintain the skin's moisture barrier, and without them, you might experience increased dryness, flakiness, and irritation.

What is an alternative to hyaluronic acid?

Best Natural Alternatives to Hyaluronic Acid
  • Aloe Vera. INCI: Aloe Barbadensis Leaf Juice Powder. ...
  • Snow Mushroom. INCI: Tremella fuciformis polysaccharide. ...
  • Panthenol. INCI: Panthenol.

Can I use vitamin C and hyaluronic acid together?

While vitamin C and hyaluronic acid can be used separately for impressive outcomes, they are also a power duo when applied in tandem. In fact, vitamin C and hyaluronic acid are often mixed - either in one serum formula, or layered in a skincare regime.

What is a pillow face?

“Pillow face” occurs when too much filler is injected into areas like the cheeks, nasolabial folds (the lines from your nose to the corners of your mouth), lips, and under-eye area. This repeated overfilling can result in a bloated, round appearance that looks far from natural.

Is there a problem with hyaluronic acid?

Topical Use: Most people can tolerate the topical application of hyaluronic acid products, like serums or creams. However, some individuals may encounter mild skin irritation, redness, or dryness, especially if they have sensitive skin.

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